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Immunoglobulin G directed against toxins A and B of Clostridium difficile in the general population and patients with antibiotic-associated diarrhea

Bacon, Alfred E. ; Fekety, Robert

Diagnostic microbiology and infectious disease, 1994-04, Vol.18 (4), p.205-209 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Immunoglobulin G directed against toxins A and B of Clostridium difficile in the general population and patients with antibiotic-associated diarrhea
Autor: Bacon, Alfred E. ; Fekety, Robert
Assuntos: Adolescent ; Adult ; Aged ; Analysis of Variance ; Antibodies, Bacterial - blood ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Bacterial Proteins ; Bacterial Toxins - immunology ; Biological and medical sciences ; Case-Control Studies ; Chi-Square Distribution ; Clostridium difficile - immunology ; Diarrhea - chemically induced ; Diarrhea - immunology ; Enterocolitis, Pseudomembranous - immunology ; Enterotoxins - immunology ; Enzyme-Linked Immunosorbent Assay ; Human bacterial diseases ; Humans ; Immunoglobulin G - blood ; Infectious diseases ; Medical sciences ; Middle Aged ; Neutralization Tests ; Recurrence ; Sensitivity and Specificity
É parte de: Diagnostic microbiology and infectious disease, 1994-04, Vol.18 (4), p.205-209
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Serum immunoglobulin G (IgG) class antibodies directed against toxins A and B of Clostridium difficile were studied using an enzyme-linked immunosorbent assay and a serum-neutralizing assay based on the MRC-5 tissue cytotoxicity assay. Of 185 individuals, 46 sera (24%) in the general population demonstrated IgG antibody, 36 (19.4%) against toxin A and 15 (8.1%) against toxin B. Antibody titer in the general population did not correlate with serum-neutralizing activity. Antibody prevalence fell with age ( P = 0.58) over 50 years. Six of ten patients with acute primary episodes of C. difficile-associated diarrhea demonstrated antibody in convalescentphase sera, predominantly directed against toxin B. Only two (28%) of seven patients with a history of relapsing C. difficile disease had demonstrable antibody.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Immunoglobulin G directed against toxins A and B of Clostridium difficile in the general population and patients with antibiotic-associated diarrhea

Bacon, Alfred E. ; Fekety, Robert

New York, NY: Elsevier Inc

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