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Genomically Recoded Organisms Expand Biological Functions

Lajoie, Marc J. ; Rovner, Alexis J. ; Goodman, Daniel B. ; Aerni, Hans-Rudolf ; Haimovich, Adrian D. ; Kuznetsov, Gleb ; Mercer, Jaron A. ; Wang, Harris H. ; Carr, Peter A. ; Mosberg, Joshua A. ; Rohland, Nadin ; Schultz, Peter G. ; Jacobson, Joseph M. ; Rinehart, Jesse ; Church, George M. ; Isaacs, Farren J.

Science (American Association for the Advancement of Science), 2013-10, Vol.342 (6156), p.357-360 [Periódico revisado por pares]

United States: American Association for the Advancement of Science

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Título:
Genomically Recoded Organisms Expand Biological Functions
Autor: Lajoie, Marc J. ; Rovner, Alexis J. ; Goodman, Daniel B. ; Aerni, Hans-Rudolf ; Haimovich, Adrian D. ; Kuznetsov, Gleb ; Mercer, Jaron A. ; Wang, Harris H. ; Carr, Peter A. ; Mosberg, Joshua A. ; Rohland, Nadin ; Schultz, Peter G. ; Jacobson, Joseph M. ; Rinehart, Jesse ; Church, George M. ; Isaacs, Farren J.
Assuntos: Amino Acid Substitution - genetics ; Amino acids ; Amino Acids - genetics ; Bacteriology ; Bacteriophage T7 - physiology ; Codon, Terminator - genetics ; E coli ; Escherichia coli ; Escherichia coli - genetics ; Escherichia coli - virology ; Escherichia coli Proteins - genetics ; Genetic Engineering ; Genome, Bacterial ; Genomics ; Microbiology ; Organisms, Genetically Modified - genetics ; Organisms, Genetically Modified - virology ; Peptide Chain Termination, Translational - genetics ; Peptide Termination Factors - genetics ; Proteins ; Translation
É parte de: Science (American Association for the Advancement of Science), 2013-10, Vol.342 (6156), p.357-360
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: We describe the construction and characterization of a genomically recoded organism (GRO). We replaced all known UAG stop codons in Escherichia coli MG1655 with synonymous UAA codons, which permitted the deletion of release factor 1 and reassignment of UAG translation function. This GRO exhibited improved properties for incorporation of nonstandard amino acids that expand the chemical diversity of proteins in vivo. The GRO also exhibited increased resistance to T7 bacteriophage, demonstrating that new genetic codes could enable increased viral resistance.
Editor: United States: American Association for the Advancement of Science
Idioma: Inglês

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Genomically Recoded Organisms Expand Biological Functions

United States: American Association for the Advancement of Science

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