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The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression

Dutta, Pranabananda ; Li, Willis X Mallo, Moises

PloS one, 2017-06, Vol.12 (6), p.e0180026-e0180026 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression
Autor: Dutta, Pranabananda ; Li, Willis X
Mallo, Moises
Assuntos: Abdomen ; Animals ; Biology and Life Sciences ; Cancer ; Cell Cycle Proteins - physiology ; Chromatin ; Chromatin Immunoprecipitation ; Chromosomes ; Deoxyribonucleic acid ; DNA ; DNA methylation ; Drosophila ; Drosophila melanogaster - genetics ; Drosophila melanogaster - metabolism ; Drosophila Proteins - physiology ; Embryonic development ; Embryos ; Epigenetic inheritance ; Epigenetics ; Gene expression ; Gene Expression Regulation ; Gene regulation ; Gene silencing ; Genes ; Genetic aspects ; Genetic engineering ; Genetic transformation ; Genomics ; Genotype & phenotype ; Group dynamics ; Immunoglobulins ; In Situ Hybridization, Fluorescence ; Insects ; Lysine ; Medicine and Health Sciences ; Physiological aspects ; Polycomb group proteins ; Polycomb-Group Proteins - genetics ; Polytene chromosomes ; Proteins ; Recruitment ; Research and Analysis Methods ; Salivary gland ; Segments ; Stem cells ; Transcription, Genetic ; Transformation ; Transgenes
É parte de: PloS one, 2017-06, Vol.12 (6), p.e0180026-e0180026
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Current address: Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, California, United States of America
Competing Interests: The authors have declared that no competing interests exist.
Descrição: The Polycomb group (PcG) proteins have been implicated in epigenetic transcriptional repression in development, stem cell maintenance and in cancer. The chromodomain protein Polycomb (Pc) is a key member of the PcG. Pc binds to the histone mark, trimethylated histone 3 lysine 27 (H3K27me3), to initiate transcriptional repression. How PcG proteins are recruited to target loci is not fully understood. Here we show that the Drosophila SERTA domain protein Taranis (Tara) is involved in transcriptional regulation of Pc target genes. Embryos lacking Tara exhibit a partial homeotic transformation of cuticular the segments, a phenotype associated with the loss of Pc function. Moreover, Drosophila embryos homozygous for a tara hypomorphic allele also misexpress engrailed, a Pc-regulated gene, and this phenotype is associated with the loss of Pc binding to the cis response element in the engrailed enhancer. In relation to that, Pc recruitment is reduced on the salivary gland polytene chromosomes and specifically at the engrailed locus. These results suggest that Tara might be required for positioning Pc to a subset of its target genes.
Editor: United States: Public Library of Science
Idioma: Inglês

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The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression

Dutta, Pranabananda ; Li, Willis X Mallo, Moises

United States: Public Library of Science

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