Idioma:

1,1-Dichloroethylene hepatotoxicity: Hypothyroidism decreases metabolism and covalent binding but not injury in the rat

Kanz, Mary F. ; Taj, Zubeda ; Moslen, Mary Treinen

Toxicology (Amsterdam), 1991, Vol.70 (2), p.213-229 [Periódico revisado por pares]

Shannon: Elsevier Ireland Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
1,1-Dichloroethylene hepatotoxicity: Hypothyroidism decreases metabolism and covalent binding but not injury in the rat
Autor: Kanz, Mary F. ; Taj, Zubeda ; Moslen, Mary Treinen
Assuntos: 1,1-dichloroethylene ; Administration, Oral ; Alcohol dehydrogenase ; Alcohol Dehydrogenase - metabolism ; Animals ; Biological and medical sciences ; Body Weight - drug effects ; Chemical and industrial products toxicology. Toxic occupational diseases ; Dichloroethylenes - pharmacokinetics ; Dichloroethylenes - toxicity ; Glutathione S-transferases ; Glutathione Transferase - metabolism ; Hepatotoxicity ; Hypothyroidism ; Hypothyroidism - metabolism ; Male ; Medical sciences ; Metabolism ; Mitochondria, Liver - drug effects ; Mitochondria, Liver - enzymology ; Mitochondria, Liver - pathology ; Radioimmunoassay ; Rats ; Rats, Inbred Strains ; Thyroidectomy ; Thyroxine - blood ; Tissue Distribution ; Toxicology ; Various organic compounds ; Vinylidene chloride
É parte de: Toxicology (Amsterdam), 1991, Vol.70 (2), p.213-229
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: Our objective was to determine if the previously reported protective effect of hypothyroidism against 1,1-dichloroethylene hepatotoxicity was associated with a change in distribution and covalent binding. Sprague-Dawley male rats were made hypothyroid (HypoT) by surgical thyroidectomy 2 weeks prior to studies and compared to euthyroid (EuT) rats. Hypothyroidism decreased body weights and liver to body weight ratios while mitochondrial non-protein sulfhydryl groups and cytosolic alcohol dehydrogenase activities were increased by 50%. Rats received a single oral dose of 100 mg [ 14C]1,1-dichloroethylene (DCE)/kg in mineral oil and were killed at 2, 4, 12 or 24 h; controls received mineral oil only. More rapid liver injury, as measured by serum alanine aminotransferase activity and histology, was present at 2 and 4 h after DCE in HypoT than EuT rats, but a similar magnitude of injury was evident at 12 and 24 h. DCE decreased liver non-protein sulfhydryl groups to a comparable extent in HypoT and EuT rats. Cytosolic glutathione S-transferase and alcohol dehydrogenase activities were decreased only in HypoT rats after DCE. HypoT rats excreted ∼30% less total [ 14C]DCE-derived label in urine and their livers. kidneys and lungs consistently contained slightly less covalently bound [ 14C]DCE-derived label. In contrast, between 1 and 4 h after DCE, greater amounts of acid-soluble and acid-precipitable [ 14C]DCE-derived label were recovered in red blood cells of HypoT rats. Our results indicate that hypothyroidism did not protect against oral DCE hepatotoxicity but was associated with a more rapid injury at early time. Concurrently, hypothyroidism was found to change the fate of [ 14C]DCE with higher amounts of 14C-label recovered at early times in red blood cells while less 14C-label was excreted in urine and bound to liver.
Editor: Shannon: Elsevier Ireland Ltd
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

1,1-Dichloroethylene hepatotoxicity: Hypothyroidism decreases metabolism and covalent binding but not injury in the rat

Kanz, Mary F. ; Taj, Zubeda ; Moslen, Mary Treinen

Shannon: Elsevier Ireland Ltd

Buscando em bases de dados remotas. Favor aguardar.