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Vinca alkaloids enhance the half-life of tumour ornithine decarboxylase

Morata, P. ; Jiménez-Mesa, J. ; Núñez de Castro, I. ; Sánchez-Jiménez, F.M.

Cancer letters, 1994-06, Vol.81 (2), p.209-213 [Periódico revisado por pares]

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Vinca alkaloids enhance the half-life of tumour ornithine decarboxylase
Autor: Morata, P. ; Jiménez-Mesa, J. ; Núñez de Castro, I. ; Sánchez-Jiménez, F.M.
Assuntos: Animals ; Biological and medical sciences ; Carcinoma, Ehrlich Tumor - enzymology ; Dose-Response Relationship, Drug ; Drug toxicity and drugs side effects treatment ; Enzyme turnover ; Half-Life ; Medical sciences ; Mice ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Ornithine decarboxylase ; Ornithine Decarboxylase - metabolism ; Pharmacology. Drug treatments ; Vinca alkaloids ; Vinca Alkaloids - pharmacology
É parte de: Cancer letters, 1994-06, Vol.81 (2), p.209-213
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Naturally occurring vinca alkaloids, vincristine and vinblastine, at micromolar concentrations enhanced the ornithine decarboxylase activity in a dose-response manner in primary cultures of Ehrlich ascites carcinoma cells. After 8 h of culture in the presence or absence of vinblastine, cycloheximide was added to the medium, a 4,5-fold increase in the half-life of the ornithine decarboxylase activity was observed in vinblastine-treated cells. This effect is probably due to the inhibition of the intracellular enzyme degradation by the vinca alkaloids.
Editor: Shannon: Elsevier Ireland Ltd
Idioma: Inglês

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