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Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability

DUVAL, A ; IACOPETTA, B ; RANZANI, G. N ; LOTHE, R. A ; THOMAS, G ; HAMELIN, R

Oncogene, 1999-11, Vol.18 (48), p.6806-6809 [Periódico revisado por pares]

Basingstoke: Nature Publishing

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Título:
Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability
Autor: DUVAL, A ; IACOPETTA, B ; RANZANI, G. N ; LOTHE, R. A ; THOMAS, G ; HAMELIN, R
Assuntos: Adenomatous polyposis coli ; anaphase-promoting complex ; b-catenin ; Base Sequence ; BAX gene ; Biological and medical sciences ; Cancer ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Colonic Neoplasms - genetics ; Colorectal cancer ; Colorectal carcinoma ; DNA, Neoplasm ; Endometrial cancer ; Endometrial Neoplasms - genetics ; Endometrium ; Female ; Frameshift Mutation ; Fundamental and applied biological sciences. Psychology ; Gastric cancer ; Genes ; hMSH3 gene ; hMSH6 gene ; Humans ; IGFIIR gene ; Microsatellite instability ; Microsatellite Repeats - genetics ; Molecular and cellular biology ; Mutation ; Phenotypes ; Repetitive Sequences, Nucleic Acid ; Stomach Neoplasms - genetics ; TCF protein ; TCF Transcription Factors ; TCF-4 gene ; TGFb-RII gene ; Transcription Factor 7-Like 2 Protein ; Transcription Factors - genetics ; Tumors ; Uterine cancer ; β-Catenin
É parte de: Oncogene, 1999-11, Vol.18 (48), p.6806-6809
Notas: ObjectType-Article-2
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Descrição: Frameshift mutations in genes containing mononucleotide repeats are often observed in cancers exhibiting a high frequency of microsatellite instability (MSI-H). Several tumor types, including colorectal, gastric, and endometrial carcinomas, display this phenotype in a significant proportion of cases. We recently showed in a large series of MSI-H colorectal tumors that approximately 40% of them exhibited frameshift mutations in an (A)9 tract within the coding region of the TCF-4 gene, a crucial member of the APC/beta-catenin/TCF pathway. In the present study, we have examined MSI-H cancers from other primary tumor sites for mutations in this new target gene. Two of 22 (9%) MSI-H primary gastric cancers and none of 23 MSI-H endometrial primary tumors and cell lines were found to have a 1 bp deletion in the TCF-4 repeat. In the same series of tumors we also looked for frameshift mutations in other coding repeats localized within the TGF beta-RII, BAX, IGFIIR, hMSH3 and hMSH6 genes. Our results suggest that the TCF-4 gene, in a similar manner to some of these latter genes, is differentially altered in MSI-H tumors from different primary sites.
Editor: Basingstoke: Nature Publishing
Idioma: Inglês

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Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability

DUVAL, A ; IACOPETTA, B ; RANZANI, G. N ; LOTHE, R. A ; THOMAS, G ; HAMELIN, R

Basingstoke: Nature Publishing

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