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No Association of Polymorphisms in Nav1.7 or Nerve Growth Factor Receptor Genes with Trigeminal Neuralgia

Costa, Grazielle Mara Ferreira ; Rocha, Luiz Paulo C ; Siqueira, Silvia Regina Dowgan Tesseroli de ; Moreira, Paula Rocha ; Almeida-Leite, Camila Megale

Pain medicine (Malden, Mass.), 2019-07, Vol.20 (7), p.1362-1369 [Periódico revisado por pares]

England: Oxford University Press

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Título:
No Association of Polymorphisms in Nav1.7 or Nerve Growth Factor Receptor Genes with Trigeminal Neuralgia
Autor: Costa, Grazielle Mara Ferreira ; Rocha, Luiz Paulo C ; Siqueira, Silvia Regina Dowgan Tesseroli de ; Moreira, Paula Rocha ; Almeida-Leite, Camila Megale
Assuntos: Alleles ; Care and treatment ; Diagnosis ; Epigenetic inheritance ; Epigenetics ; Ethylenediaminetetraacetic acid ; Gene frequency ; Genes ; Genetic aspects ; Genetic research ; Growth factors ; Medical research ; Medicine, Experimental ; Nerve growth factor ; Neuralgia ; Neuralgia, Trigeminal ; Pain ; Pain perception ; Polymerase chain reaction ; Scientific equipment and supplies industry ; Single nucleotide polymorphisms ; Sodium channels (voltage-gated) ; Trigeminal nerve ; TrkA protein
É parte de: Pain medicine (Malden, Mass.), 2019-07, Vol.20 (7), p.1362-1369
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Trigeminal neuralgia is defined as a sudden severe shock-like pain within the distribution of the trigeminal nerve. Pain is a subjective experience that is influenced by gender, culture, environment, psychological traits, and genes. Sodium channels and nerve growth factor play important roles in the transmission of nociceptive signals and pain. The aim of this study was to investigate the occurrence of Nav1.7 sodium channel and nerve growth factor receptor TrkA gene polymorphisms (SCN9A/rs6746030 and NTRK1/rs633, respectively) in trigeminal neuralgia patients. Ninety-six subjects from pain specialty centers in the southeastern region of Brazil were divided into 2 groups: 48 with classical trigeminal neuralgia diagnosis and 48 controls. Pain was evaluated using the visual analog scale and multidimensional McGill Pain Questionnaire. Genomic DNA was obtained from oral swabs in all individuals and was analyzed by real-time polymerase chain reaction. No association was observed between evaluated polymorphisms and trigeminal neuralgia. For allele analyses, patients and controls had similar frequencies for both genes. Genotype distribution or allele frequencies of polymorphisms analyzed here did not correlate to pain scores. Although no association of evaluated polymorphisms and trigeminal neuralgia diagnosis or pain severity was observed, our data do not exclude the possibility that other genotypes affecting the expression of Nav1.7 or TrkA are associated with the disease. Further studies should investigate distinct genetic polymorphisms and epigenetic factors that may be important in expression of these molecules.
Editor: England: Oxford University Press
Idioma: Inglês

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No Association of Polymorphisms in Nav1.7 or Nerve Growth Factor Receptor Genes with Trigeminal Neuralgia

Costa, Grazielle Mara Ferreira ; Rocha, Luiz Paulo C ; Siqueira, Silvia Regina Dowgan Tesseroli de ; Moreira, Paula Rocha ; Almeida-Leite, Camila Megale

England: Oxford University Press

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