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Expression cloning and intracellular localization of a human ZF5 homologue

Sugiura, Kazumitsu ; Muro, Yoshinao ; Nagai, Yasuo ; Kamimoto, Takahiro ; Wakabayashi, Takashi ; Ohashi, Masaru ; Hagiwara, Masatoshi

Biochimica et biophysica acta. Gene structure and expression, 1997-05, Vol.1352 (1), p.23-26 [Periódico revisado por pares]

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Título:
Expression cloning and intracellular localization of a human ZF5 homologue
Autor: Sugiura, Kazumitsu ; Muro, Yoshinao ; Nagai, Yasuo ; Kamimoto, Takahiro ; Wakabayashi, Takashi ; Ohashi, Masaru ; Hagiwara, Masatoshi
Assuntos: BTB/POZ domain ; Nuclear localization ; ZF5 ; Zinc finger
É parte de: Biochimica et biophysica acta. Gene structure and expression, 1997-05, Vol.1352 (1), p.23-26
Descrição: We isolated a cDNA encoding a human homologue of ZF5 (hZF5), which has five Kruppel-like C2H2 type zinc fingers at carboxyl terminus and the BTB/POZ (poxvirus and zinc finger) at the amino terminus, using autoimmune sera from a patient with overlap syndrome (dermatomyositis and scleroderma). Sequencing of the entire cDNA revealed an open reading frame (ORF) of 1349 bp with a deduced protein sequence of 449 amino acid residues and a calculated molecular weight of 51.3 kDa. The deduced amino acid sequence of hZF5 is highly homologous to mouse ZF5 (99.3% identity). Immunofluorescence studies revealed that HA-tagged hZF5 transiently expressed in COS-7 cells showed the nuclear dot pattern in the BTB/POZ domain-dependent manner.
Editor: Elsevier B.V
Idioma: Inglês

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