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1-deoxynojirimycin inhibits glucose absorption and accelerates glucose metabolism in streptozotocin-induced diabetic mice

Li, You-Gui ; Ji, Dong-Feng ; Zhong, Shi ; Lin, Tian-Bao ; Lv, Zhi-Qiang ; Hu, Gui-Yan ; Wang, Xin

Scientific reports, 2013-03, Vol.3 (1), p.1377, Article 1377 [Periódico revisado por pares]

England: Nature Publishing Group

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1-deoxynojirimycin inhibits glucose absorption and accelerates glucose metabolism in streptozotocin-induced diabetic mice
Autor: Li, You-Gui ; Ji, Dong-Feng ; Zhong, Shi ; Lin, Tian-Bao ; Lv, Zhi-Qiang ; Hu, Gui-Yan ; Wang, Xin
Assuntos: 1-Deoxynojirimycin - pharmacology ; Animals ; Biological Transport - drug effects ; Blood Glucose - drug effects ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Experimental - metabolism ; Enzyme Inhibitors - pharmacology ; Enzymes ; Gene expression ; Gluconeogenesis ; Gluconeogenesis - drug effects ; Glucose ; Glucose - metabolism ; Glucose tolerance ; Glucose transport ; Glucose Transport Proteins, Facilitative - biosynthesis ; Glucose Transport Proteins, Facilitative - drug effects ; Glucose transporter ; Glucose Transporter Type 2 - biosynthesis ; Glucose Transporter Type 2 - genetics ; Glycolysis ; Glycolysis - drug effects ; Intestinal Absorption - drug effects ; Intestine ; Intestines - drug effects ; Intestines - metabolism ; Intravenous administration ; Male ; Metabolism ; Mice ; Mice, Inbred ICR ; mRNA ; Protein expression ; Proteins ; RNA, Messenger - biosynthesis ; Rodents ; Sodium-Glucose Transporter 1 - biosynthesis ; Sodium-Glucose Transporter 1 - genetics ; Sodium-Potassium-Exchanging ATPase - biosynthesis ; Sodium-Potassium-Exchanging ATPase - genetics ; Streptozocin
É parte de: Scientific reports, 2013-03, Vol.3 (1), p.1377, Article 1377
Descrição: We investigated the role of 1-deoxynojirimycin (DNJ) on glucose absorption and metabolism in normal and diabetic mice. Oral and intravenous glucose tolerance tests and labeled (13)C6-glucose uptake assays suggested that DNJ inhibited intestinal glucose absorption in intestine. We also showed that DNJ down-regulated intestinal SGLT1, Na(+)/K(+)-ATP and GLUT2 mRNA and protein expression. Pretreatment with DNJ (50 mg/kg) increased the activity, mRNA and protein levels of hepatic glycolysis enzymes (GK, PFK, PK, PDE1) and decreased the expression of gluconeogenesis enzymes (PEPCK, G-6-Pase). Assays of protein expression in hepatic cells and in vitro tests with purified enzymes indicated that the increased activity of glucose glycolysis enzymes was resulted from the relative increase in protein expression, rather than from direct enzyme activation. These results suggest that DNJ inhibits intestinal glucose absorption and accelerates hepatic glucose metabolism by directly regulating the expression of proteins involved in glucose transport systems, glycolysis and gluconeogenesis enzymes.
Editor: England: Nature Publishing Group
Idioma: Inglês

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1-deoxynojirimycin inhibits glucose absorption and accelerates glucose metabolism in streptozotocin-induced diabetic mice

Li, You-Gui ; Ji, Dong-Feng ; Zhong, Shi ; Lin, Tian-Bao ; Lv, Zhi-Qiang ; Hu, Gui-Yan ; Wang, Xin

England: Nature Publishing Group

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