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Overexpression of inducible nitric oxide synthase and accumulation of 8-OHdG in nasopharyngeal carcinoma

Segawa, Y ; Oda, Y ; Yamamoto, H ; Uryu, H ; Shiratsuchi, H ; Hirakawa, N ; Tomita, K ; Yamamoto, T ; Oda, S ; Yamada, T ; Komune, S ; Tsuneyoshi, M

Histopathology, 2008-01, Vol.52 (2), p.213-223 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Overexpression of inducible nitric oxide synthase and accumulation of 8-OHdG in nasopharyngeal carcinoma
Autor: Segawa, Y ; Oda, Y ; Yamamoto, H ; Uryu, H ; Shiratsuchi, H ; Hirakawa, N ; Tomita, K ; Yamamoto, T ; Oda, S ; Yamada, T ; Komune, S ; Tsuneyoshi, M
Assuntos: 8-OHdG ; Adaptor Proteins, Signal Transducing ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Cytoskeletal Proteins ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - genetics ; Deoxyguanosine - metabolism ; DNA Damage - genetics ; DNA, Neoplasm - genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; iNOS ; Intracellular Signaling Peptides and Proteins - genetics ; Intracellular Signaling Peptides and Proteins - metabolism ; Investigative techniques, diagnostic techniques (general aspects) ; Kaplan-Meier Estimate ; LIM Domain Proteins ; Male ; Medical sciences ; Middle Aged ; Mutation ; nasopharyngeal carcinoma ; Nasopharyngeal Neoplasms - metabolism ; Nasopharyngeal Neoplasms - pathology ; Neoplasms, Squamous Cell - metabolism ; Neoplasms, Squamous Cell - pathology ; Nitric Oxide Synthase Type II - genetics ; Nitric Oxide Synthase Type II - metabolism ; Otorhinolaryngology. Stomatology ; oxidative stress ; Oxidative Stress - genetics ; p53 ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; RNA, Messenger - metabolism ; RNA, Viral - metabolism ; Tumor Suppressor Protein p53 - genetics ; Tumor Suppressor Protein p53 - metabolism ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
É parte de: Histopathology, 2008-01, Vol.52 (2), p.213-223
Notas: istex:773DAE196D817FEB746F4D5ACC1CE272C2679157
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ArticleID:HIS2920
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Aims: Nitric oxide (NO), produced by inducible NO synthase (iNOS), has been suggested to cause oxidative stress, leading to 8‐hydroxydeoxyguanosine (8‐OHdG) accumulation and subsequent transversion mutation of DNA. The aim was to evaluate iNOS expression and the status of oxidative stress in nasopharyngeal carcinoma (NPC). Methods and results: Seventy‐three cases of NPC were investigated to examine the immunohistochemical expression of iNOS, 8‐OHdG and latent membrane protein‐1 (LMP‐1) and Epstein–Barr virus‐encoded small RNA (EBER) expression using in situ hybridization. iNOS mRNA expression and p53 gene mutations were also assessed. Overexpression of iNOS, LMP‐1 and EBER was observed in 62 (84.9%), 28 (38.4%) and 53 (72.6%) cases respectively. p53 gene mutation was found in 10 of 73 (13.7%) cases. Immunohistochemical iNOS expression was associated with the 8‐OHdG labelling index, iNOS mRNA expression and p53 gene alteration (P < 0.0001, P = 0.016 and 0.0082 respectively). Conclusions: Our present findings suggest that the expression of iNOS induces oxidative stress in NPC. Although the presence of p53 mutation was associated with iNOS overexpression, the type of acid–base change of p53 was transition, but not transversion, which suggests that the p53 gene is not the direct target of DNA damage by 8‐OHdG accumulation.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Overexpression of inducible nitric oxide synthase and accumulation of 8-OHdG in nasopharyngeal carcinoma

Segawa, Y ; Oda, Y ; Yamamoto, H ; Uryu, H ; Shiratsuchi, H ; Hirakawa, N ; Tomita, K ; Yamamoto, T ; Oda, S ; Yamada, T ; Komune, S ; Tsuneyoshi, M

Oxford, UK: Blackwell Publishing Ltd

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