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Chromosomal polymorphisms are associated with female infertility and adverse reproductive outcomes after infertility treatment: a 7-year retrospective study

Cheng, Ran ; Ma, Yaxian ; Nie, Ying ; Qiao, Xiaoyong ; Yang, Zhilan ; Zeng, Rujun ; Xu, Liangzhi

Reproductive biomedicine online, 2017-07, Vol.35 (1), p.72-80 [Periódico revisado por pares]

Netherlands: Elsevier Ltd

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Título:
Chromosomal polymorphisms are associated with female infertility and adverse reproductive outcomes after infertility treatment: a 7-year retrospective study
Autor: Cheng, Ran ; Ma, Yaxian ; Nie, Ying ; Qiao, Xiaoyong ; Yang, Zhilan ; Zeng, Rujun ; Xu, Liangzhi
Assuntos: Abortion, Spontaneous - epidemiology ; Abortion, Spontaneous - genetics ; chromosomal polymorphism ; Female ; female infertility ; Humans ; Incidence ; Infertility, Female - epidemiology ; Infertility, Female - genetics ; Logistic Models ; Obstetrics and Gynecology ; Polymorphism, Genetic ; Pregnancy ; Pregnancy Outcome ; preterm birth ; Retrospective Studies ; spontaneous miscarriage
É parte de: Reproductive biomedicine online, 2017-07, Vol.35 (1), p.72-80
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Abstract Data from 19,950 women were retrospectively analysed to determine the effect of chromosomal polymorphisms on female infertility and pregnancy outcome; fertile women were used as controls. Frequency of chromosomal polymorphisms and adverse pregnancy outcomes were compared between groups. A significantly higher incidence of chromosomal polymorphisms was found in total infertile patients, and patients with tubal infertility, ovulatory dysfunction, cervical and uterine abnormalities, and unexplained infertility compared with controls (5.53% [ P < 0.001], 4.86% [ P = 0.012] 5.40% [ P < 0.001], 5.75% [ P < 0.001] and 8.51% [ P < 0.001], versus 3.74%, respectively). Infertile women had a higher incidence of 9qh+ and inv(9) compared with controls ( P < 0.001 and P = 0.027). Logistic regression analysis showed an effect of chromosomal polymorphisms on female infertility (adjusted OR 1.662, 95% CI 1.551 to 1.796, P < 0.001). All couples reported a phenotypically normal baby. In control and tubal infertility groups, miscarriage rates were higher in women with chromosomal polymorphisms than in women with normal chromosomes (4.95% versus 0.96%, P = 0.001 and 6.17% versus 1.08%, P < 0.001). Preterm birth rate showed a similar trend. Chromosomal polymorphisms adversely affected spontaneous miscarriage rates (adjusted OR 1.625, 95% CI 1.514 to 1.769, P = 0.005).
Editor: Netherlands: Elsevier Ltd
Idioma: Inglês

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Chromosomal polymorphisms are associated with female infertility and adverse reproductive outcomes after infertility treatment: a 7-year retrospective study

Cheng, Ran ; Ma, Yaxian ; Nie, Ying ; Qiao, Xiaoyong ; Yang, Zhilan ; Zeng, Rujun ; Xu, Liangzhi

Netherlands: Elsevier Ltd

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