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Abuse and Diversion of Immediate Release Opioid Analgesics as Compared to Extended Release Formulations in the United States

Iwanicki, Janetta L ; Severtson, S Geoff ; McDaniel, Heather ; Rosenblum, Andrew ; Fong, Chunki ; Cicero, Theodore J ; Ellis, Matthew S ; Kurtz, Steven P ; Buttram, Mance E ; Dart, Richard C Landau, Ruth

PloS one, 2016-12, Vol.11 (12), p.e0167499 [Revista revisada por pares]

United States: Public Library of Science

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Abuse and Diversion of Immediate Release Opioid Analgesics as Compared to Extended Release Formulations in the United States
Autor: Iwanicki, Janetta L ; Severtson, S Geoff ; McDaniel, Heather ; Rosenblum, Andrew ; Fong, Chunki ; Cicero, Theodore J ; Ellis, Matthew S ; Kurtz, Steven P ; Buttram, Mance E ; Dart, Richard C
Landau, Ruth
Materias: Addictions ; Adjustment ; Alcohol ; Analgesics ; Analgesics, Opioid - adverse effects ; Biology and Life Sciences ; Bypasses ; Comparative analysis ; Complications and side effects ; Delayed-Action Preparations - adverse effects ; Departments ; Disease control ; Dosage and administration ; Drug abuse ; Drug administration and dosage ; Drug diversion ; Drug Prescriptions - statistics & numerical data ; Drug use ; Drugs ; Engineering and Technology ; Epidemics ; FDA approval ; Formulations ; Health disparities ; Health surveillance ; Hospitals ; Humans ; Laws, regulations and rules ; Medicine and Health Sciences ; Methods ; Narcotics ; Opioid-Related Disorders - epidemiology ; Opioid-Related Disorders - etiology ; Opioid-Related Disorders - prevention & control ; Opioids ; Pain ; Patients ; Pharmaceutical industry ; Poison Control Centers - statistics & numerical data ; Poisson density functions ; Prescription drugs ; Prevalence ; Prevention ; Primary care ; Psychiatry ; Public health ; Regression Analysis ; Risk Assessment - statistics & numerical data ; Risk Factors ; Social Sciences ; Statistical analysis ; Substance abuse treatment ; Substance Abuse Treatment Centers - statistics & numerical data ; Surveillance ; United States - epidemiology
Es parte de: PloS one, 2016-12, Vol.11 (12), p.e0167499
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no additional competing interests exist.
Conceptualization: JLI RCD.Data curation: SGS HM.Formal analysis: SGS HM.Investigation: AR CF TJC MSE SPK MEB.Methodology: JLI SGS HM RCD.Project administration: RCD.Supervision: RCD.Validation: SGS HM.Visualization: JLI SGS HM.Writing – original draft: JLI.Writing – review & editing: JLI SGS HM AR TJC MSE SPK MEB RCD.
Descripción: Therapeutic use and abuse of prescription opioids in the United States increased substantially between 1990 and 2010. The Centers for Disease Control estimated deaths related to pharmaceutical opioids reached nearly 19,000 in 2014. Of prescription opioids sold, 10% are extended release (ER) and 90% immediate release (IR). However, most regulations and interventions have focused on decreasing ER abuse. Our objective was to compare rates of abuse and diversion of ER and IR opioid analgesics over time using multiple surveillance programs. Rates of abuse and diversion of ER and IR opioid formulations were compared using data from four surveillance programs in the Researched Abuse, Diversion and Addiction Related Surveillance (RADARS®) System. Data were evaluated from 2009 through 2015, and Poisson regression used to compare IR and ER opioid cases over time. From 2009 to 2015, IR opioids were prescribed at a rate 12 to 16 times higher than ER. In the Poison Center Program, population-adjusted rates of Intentional Abuse for IR were 4.6 fold higher than ER opioids (p<0.001). In the Drug Diversion Program, population-adjusted rates of diversion were 6.1 fold higher for IR than ER opioids (p<0.001). In the Opioid Treatment Program, population-adjusted rates of endorsements for abuse were 1.6 fold higher for IR opioids than ER (p = 0.002). In the Survey of Key Informants' Patients Program, population-adjusted rates of endorsements for abuse were 1.5 fold higher for IR opioids than ER (p<0.001). Between 2009 and 2015, IR opioids were prescribed at a much higher rate than ER opioids. Results from four surveillance programs show population-adjusted rates of prescription opioid abuse were markedly higher for IR than ER medications. For the greatest public health benefit, future interventions to decrease prescription opioid abuse should focus on both IR and ER formulations.
Editor: United States: Public Library of Science
Idioma: Inglés

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Abuse and Diversion of Immediate Release Opioid Analgesics as Compared to Extended Release Formulations in the United States

Iwanicki, Janetta L ; Severtson, S Geoff ; McDaniel, Heather ; Rosenblum, Andrew ; Fong, Chunki ; Cicero, Theodore J ; Ellis, Matthew S ; Kurtz, Steven P ; Buttram, Mance E ; Dart, Richard C Landau, Ruth

United States: Public Library of Science

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