skip to main content
Language:
Resource type Show Results with: Show Results with: Index

Chromosome Organization within the Nucleus

Marshall, Wallace F. ; Markaki, Yolanda ; Hübner, Barbara ; Zunhammer, Andreas ; Strickfaden, Hilmar ; Beichmanis, Sven ; Heß, Martin ; Schermelleh, Lothar ; Cremer, Marion ; Cremer, Christoph Meyers, Robert A.

Reviews in Cell Biology and Molecular Medicine, 2012

Weinheim, Germany: Wiley‐VCH Verlag GmbH & Co. KGaA

Full text available

Citations Cited by
  • Title:
    Chromosome Organization within the Nucleus
  • Author: Marshall, Wallace F. ; Markaki, Yolanda ; Hübner, Barbara ; Zunhammer, Andreas ; Strickfaden, Hilmar ; Beichmanis, Sven ; Heß, Martin ; Schermelleh, Lothar ; Cremer, Marion ; Cremer, Christoph
  • Meyers, Robert A.
  • Subjects: Cell Biology ; Epigenetic Regulation and Epigenomics
  • Is Part Of: Reviews in Cell Biology and Molecular Medicine, 2012
  • Description: Quantitative analyses of the dynamic organization of chromosomes in cycling and postmitotic cells are indispensable attributes of a systematic approach, necessary to describe the structural basis of nuclear functions such as cell type‐specific gene expression patterns. It is now known that this organization changes to a surprising extent during normal development, as well as normal and pathological cell differentiation. To set the stage, a brief account is provided of the origins of chromosome research, including the seminal observations that led Theodor Boveri to his concept of chromosome territories (CTs) in the early twentieth century. Compelling experimental proof is then provided in favor of CTs, which was obtained during the 1970s and 1980s. Thereafter, current evidence is described for nonrandom nuclear CT arrangements and various models of CT organization, which have been developed to date. The chapter is concluded with a vision to generate complete four‐dimensional (4‐D; space–time) maps of nuclear landscapes from a range of species selected from different parts of the evolutionary tree. The generation of such 4‐D maps is important to distinguish evolutionary highly conserved features from species and cell type‐specific peculiarities of nuclear architectures. Today, their generation has become possible based on a combination of three‐dimensional (3‐D) and 4‐D light optical nanoscopy, 3‐D electron microscopic approaches with new high‐throughput genome‐wide analyses of nonrandom DNA–DNA proximity patterns, as well as protein–protein and DNA–protein interactions within and between CTs.
    The interphase nucleus provides the structural context for chromosome biology, including gene expression and recombination. The organization of chromosomes within the nucleus is not random. Instead, chromosomes are organized by specific constraints, including interactions of specific loci with the nuclear envelope. This interaction may involve both nuclear lamins and nuclear pore complexes. Specific nuclear envelope attachments, together with a persisting remnant of the anaphase chromosome configuration, leads to chromosomes being organized into nonoverlapping territories with specific orientations. Superimposed on this organization is a high degree of chromosome mobility driven by diffusion. Because chromosomes are constrained by nuclear envelope attachments, their diffusion is constrained, with each locus able to explore only a limited subregion of the nucleus. This constrained mobility, together with the nonrandom positional organization of chromosomes, predicts a high degree of nonrandomness in the pattern of interchromosomal interactions.
  • Publisher: Weinheim, Germany: Wiley‐VCH Verlag GmbH & Co. KGaA
  • Language: English
Back to results list
Go to Previous pagePrevious Result  9 NextGo to Next page

  • Implemented by: ABCD-USP USP   Social Network Logos: Freepik

Searching Remote Databases, Please Wait

  • Searching for
  • inscope:(USP_VIDEOS),scope:("PRIMO"),scope:(USP_FISICO),scope:(USP_EREVISTAS),scope:(USP),scope:(USP_EBOOKS),scope:(USP_PRODUCAO),primo_central_multiple_fe
  • Show me what you have so far