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Effect of the probiotic Saccharomyces cerevisiae on ligature-induced periodontitis in rats

Garcia, V. G. ; Knoll, L. R. ; Longo, M. ; Novaes, V. C. N. ; Assem, N. Z. ; Ervolino, E. ; de Toledo, B. E. C. ; Theodoro, L. H.

Journal of periodontal research, 2016-02, Vol.51 (1), p.26-37 [Periódico revisado por pares]

United States: Blackwell Publishing Ltd

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  • Título:
    Effect of the probiotic Saccharomyces cerevisiae on ligature-induced periodontitis in rats
  • Autor: Garcia, V. G. ; Knoll, L. R. ; Longo, M. ; Novaes, V. C. N. ; Assem, N. Z. ; Ervolino, E. ; de Toledo, B. E. C. ; Theodoro, L. H.
  • Assuntos: Alveolar Bone Loss ; Animals ; Dental Scaling ; Dentistry ; Ligation ; Periodontitis ; Probiotics ; Rats ; Rats, Wistar ; Saccharomyces cerevisiae
  • É parte de: Journal of periodontal research, 2016-02, Vol.51 (1), p.26-37
  • Notas: ArticleID:JRE12274
    istex:8FD4EB17CEE56F42C78985DEDB88D5C57F7D25D2
    Pro-Reitoria de Pesquisa da UNESP
    ark:/67375/WNG-QBS14QRS-Z
    "FUNDUNESP" - No. 0468/011/14-PROPe/CDC
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Background and Objective This study assessed the effects of the local use of Saccharomyces cerevisiae as monotherapy and as an adjuvant to the mechanical treatment of ligature‐induced periodontitis in rats. Material and Methods Periodontitis was induced in 72 rats via the installation of a ligature around the mandibular first molar. After 7 d, the ligature was removed and the rats were placed in one of the following groups: no treatment (C; n = 18); scaling and root planing (SRP; n = 18); local irrigation with probiotics (PRO; n = 18); and SRP followed by local irrigation with probiotics (SRP/PRO; n = 18). Six rats from each group were killed at 7, 15 and 30 d. The histological characteristics, alveolar bone loss (ABL) and immunolabeling of tumor necrosis factor alpha (TNF‐α), interleukin‐1beta (IL‐1β), interleukin‐10 (IL‐10) and TRAP on the furcation area of the first molar were assessed. Results The PRO group showed features of acceleration of the tissue‐repair process during the entire experiment. On day 15, there was less ABL in the SRP/PRO group compared with the C group. There were fewer TRAP‐positive cells in the SRP and SRP/PRO groups at 30 d. There was less immunostaining for TNF‐α in the PRO and SRP/PRO groups and less immunostaining for IL‐1β in the PRO group. However, there was more immunostaining for IL‐10 in the PRO group on day 15. Conclusion Local use of the probiotic did not result in any adverse effects on periodontal tissues. When used as monotherapy or as an adjuvant, the probiotic was effective at controlling periodontitis in rats.
  • Editor: United States: Blackwell Publishing Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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