Risk assessment of
accidental
falls
in patients taking trazodone, quetiapine, or risperidone for insomnia: A single‐center, case–control study
ABCD PBi
Risk assessment of
accidental
falls
in patients taking trazodone, quetiapine, or risperidone for insomnia: A single‐center, case–control study
Autor:
Shimizu, Yoshihito
;
Taga, Masatoshi
;
Takahashi, Yoshimitsu
;
Yamamoto, Yasuhiko
;
Masauji, Togen
Assuntos:
accidental
fall
;
Accidental
Falls
;
Age
;
Alzheimer's disease
;
Antidepressants
;
Antipsychotics
;
Benzodiazepines
;
Case-Control Studies
;
Child
;
Delirium
;
Dementia
;
Diabetes
;
Falls
;
Hemorrhage
;
Hospitals
;
Humans
;
Insomnia
;
Length of stay
;
Multivariate analysis
;
Neurology
;
Neurosurgery
;
Ophthalmology
;
Patients
;
Psychotropic drugs
;
quetiapine
;
Quetiapine Fumarate - adverse effects
;
Regression analysis
;
Risk Assessment
;
Risk factors
;
risperidone
;
Risperidone - adverse effects
;
Sleep
;
Sleep Initiation and Maintenance Disorders - drug therapy
;
Stroke
;
trazodone
;
Trazodone - adverse effects
;
Variables
É parte de:
Neuropsychopharmacology reports, 2022-12, Vol.42 (4), p.532-537
Notas:
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição:
Aim No consensus has been reached on the association between the risk of
falls
and antipsychotic and antidepressant drug use. In this study, we evaluated the risk of
falls
with trazodone, risperidone, and quetiapine, which are recommended for use at Kanazawa Medical University Hospital. Methods We reviewed all patients who were admitted to Kanazawa Medical University Hospital between January 1st and December 31st, 2018. We excluded those aged <20 years and those admitted to pediatric, intensive care, and psychiatric wards. Finally, 9273 patients were included. We reviewed the incidence in these patients of
accidental
falls
reported to the medical safety department. We noted whether these patients received trazodone, quetiapine, or risperidone. We also observed whether they were taking a benzodiazepine receptor agonist, which is a known risk factor. We further examined each patient's age, sex, the department they were visiting, and their diseases. Patients were considered to have taken medication if it was administered within 24 hours before an accidental fall. Multiple logistic regression analysis was used to evaluate the risk of accidental fall. Results Multivariate analysis showed that the adjusted odds ratios (OR) for each medication (with 95% confidence intervals) were: trazodone (OR, 0.47 [0.27–0.80]), quetiapine (OR, 1.06 [0.46–2.46]), and risperidone (OR, 0.82 [0.41–1.63]). Conclusion The association of risperidone and quetiapine with accidental falls was unclear. Interestingly, however, trazodone may help reduce the risk, which makes it a potential pharmacologic treatment option for insomnia in patients at high risk for accidental falls.
Editor:
United States: John Wiley & Sons, Inc
Idioma:
Inglês