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Antiplatelet activity of Croton celditifolius

Neiva, Teresinha de Jesus Carvalho ; Moraes, Ana Carolina Rabello de ; Buchele, Carlos ; Pizzolatti, Moacir Geraldo ; D'Amico, Elbio Antônio ; Fries, Diana Marli ; Rocha, Tania Rubia Flores da

Revista brasileira de ciências farmacêuticas, 2008-03, Vol.44 (1), p.127-132

Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São Paulo

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  • Título:
    Antiplatelet activity of Croton celditifolius
  • Autor: Neiva, Teresinha de Jesus Carvalho ; Moraes, Ana Carolina Rabello de ; Buchele, Carlos ; Pizzolatti, Moacir Geraldo ; D'Amico, Elbio Antônio ; Fries, Diana Marli ; Rocha, Tania Rubia Flores da
  • Assuntos: PHARMACOLOGY & PHARMACY
  • É parte de: Revista brasileira de ciências farmacêuticas, 2008-03, Vol.44 (1), p.127-132
  • Descrição: Croton celtidifolius Baill is a tree found in the Atlantic Forest South of Brazil, mainly in Santa Catarina. The bark and leaf infusions of this medicinal plant have been popularly used for the treatment of inflammatory diseases. The anti-aggregant activity of C. celtidifolius crude extract (CE) and the column chromatography (CC) isolated compounds flavonoids, catechin and gallocatechin were evaluated in human blood platelets. The platelet-rich plasma (PRP) was incubated with different concentrations of flavonóides (50 - 200 µg/mL) to be tested before platelet aggregation was induced by the agonists adenosine 5'diphosphate (ADP) and collagen. At 200 µg/mL the CE, catechin and gallocatechin markedly inhibited platelet aggregation with the aggregant agents. Using ATP production as an index of platelet secretory capacity, we observed a decreased production of ATP in platelets treated with flavonoids when stimulated by collagen. On the other hand, the flavonoids did not promote inhibitory effect on prothrombin time (PT), thromboplastin time (APTT) and thrombin time (TT). In conclusion, these observations suggest that C. celtidifolius is likely to exert an inhibitory action on platelets in vitro by suppressing secretion and platelet aggregation.
  • Editor: Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São Paulo
  • Idioma: Inglês;Português
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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