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Primordial odontogenic tumour: clinicopathological analysis of six cases of a previously undescribed entity

Mosqueda-Taylor, Adalberto ; Pires, Fabio Ramoa ; Aguirre-Urízar, José Manuel ; Carlos-Bregni, Roman ; de la Piedra-Garza, José Mario ; Martínez-Conde, Rafael ; Martínez-Mata, Guillermo ; Carreño-Álvarez, Sergio J ; da Silveira, Henrique Martins ; de Barros Dias, Bruno Santos ; de Almeida, Oslei Paes

Histopathology, 2014-11, Vol.65 (5), p.606-612 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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  • Título:
    Primordial odontogenic tumour: clinicopathological analysis of six cases of a previously undescribed entity
  • Autor: Mosqueda-Taylor, Adalberto ; Pires, Fabio Ramoa ; Aguirre-Urízar, José Manuel ; Carlos-Bregni, Roman ; de la Piedra-Garza, José Mario ; Martínez-Conde, Rafael ; Martínez-Mata, Guillermo ; Carreño-Álvarez, Sergio J ; da Silveira, Henrique Martins ; de Barros Dias, Bruno Santos ; de Almeida, Oslei Paes
  • Assuntos: Adolescent ; Biomarkers, Tumor - metabolism ; dental follicle ; dental papilla ; Epithelium - pathology ; Female ; Humans ; Immunohistochemistry ; Jaw Neoplasms - classification ; Jaw Neoplasms - metabolism ; Jaw Neoplasms - pathology ; Jaw Neoplasms - therapy ; jaws ; Male ; Odontogenic Tumors - classification ; Odontogenic Tumors - metabolism ; Odontogenic Tumors - pathology ; Odontogenic Tumors - therapy ; odontogenic tumour ; tooth primordium
  • É parte de: Histopathology, 2014-11, Vol.65 (5), p.606-612
  • Notas: istex:67BDCC0042CF93D9D42EC3E6AAF740A6A227310D
    Figure S1. Macroscopic aspect of tumour of case 2. Well defined white solid homogeneous tumour.Figure S2. Clear separation of tumour from adjacent molar tooth in case 4.Figure S3. Case 5. Microscopic aspect demonstrating loose and myxoid appearing fibrous tissue covered over all its periphery by columnar epithelium and a thin fibrous capsule.Figure S4. Case 3. Tumour composed of loose fibrous tissue and scattered fusiform and stellate fibroblasts, completely covered by columnar or cuboidal epithelium. Tangential sectioning shows an epithelial cord crossing some areas of the multilobulated tumour.Figure S5. Case 1. Tumour composed of variably cellular mesenchymatous tissue surrounded by columnar or cuboidal epithelium.Figure S6. Periphery of tumour in case 2. Note the columnar epithelium surrounding the loose fibrous tissue.Figure S7. Case 4. Cellular mesenchyme-like tissue surrounded at the periphery by columnar epithelium.Figure S8. Case 6. Incisional biopsy showed the same features found in the other five cases.Figure S9. Loose and myxoid appearing fibrous tissue covered by columnar epithelium evident in case 5.
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  • Descrição: Aim To describe the clinicopathological and immuno‐histochemical features of six tumours that do not fulfil the criteria of any of the currently classified odontogenic tumours. Methods and results The patients were three males and three females, whose ages ranged from 3 years to 18 years (mean, 11.05 years). In all cases there were well‐defined radiolucencies associated with unerupted teeth apparently showing a pericoronal relationship. Microscopically, all tumours were composed of variably cellular loose fibrous tissue with areas similar to dental papilla, entirely surrounded by cuboidal to columnar epithelium resembling the internal epithelium of the enamel organ. Mesenchymal tissue was positive only for vimentin, and Ki67 expression was very low (<2%). The epithelium was positive for CK AE1/AE3, CK5, CK14, and CK19, but negative for CK18 and CK20. All cases showed clear demarcation from the surrounding bone, and were surgically removed, with no recurrences after follow‐up ranging from 6 months to 20 years. Conclusions These findings differ from those observed in other odontogenic lesions, such as ameloblastic fibroma, odontogenic myxoma, odontogenic fibroma, and hyperplastic dental follicles. The term primordial odontogenic tumour is proposed to describe this novel lesion.
  • Editor: England: Blackwell Publishing Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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