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Design of liposomes as drug delivery system for therapeutic applications

Guimarães, Diana ; Cavaco-Paulo, Artur ; Nogueira, Eugénia

International journal of pharmaceutics, 2021-05, Vol.601, p.120571, Article 120571 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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  • Título:
    Design of liposomes as drug delivery system for therapeutic applications
  • Autor: Guimarães, Diana ; Cavaco-Paulo, Artur ; Nogueira, Eugénia
  • Assuntos: Drug delivery ; Liposome characterization ; Liposome production ; Liposomes ; Market liposomes
  • É parte de: International journal of pharmaceutics, 2021-05, Vol.601, p.120571, Article 120571
  • Descrição: [Display omitted] •Liposomes represent a powerful delivery system for several drugs;•Methods for liposomal production: conventional and novel;•Properties of the liposomal formulation such as its characterization, stabilization and limitations.•Therapeutic applications of liposomes, focuses on marketed liposomes. Liposomes are spherical vesicles consisting of one or more concentric phospholipid bilayers enclosing an aqueous core. Being both nontoxic and biodegradable, liposomes represent a powerful delivery system for several drugs. They have improved the therapeutic efficacy of drugs through stabilizing compounds, overcoming obstacles to cellular and tissue uptake and increasing drug biodistribution to target sites in vivo, while minimizing systemic toxicity. This review offers an overview of liposomes, thought the exploration of their key fundamentals. Initially, the main design aspects to obtain a successful liposomal formulation were addressed, following the techniques for liposome production and drug loading. Before application, liposomes required an extensive characterization to assurance in vitro and in vivo performance. Thus, several properties to characterize liposomes were explored, such as size, polydispersity index, zeta potential, shape, lamellarity, phase behavior, encapsulation efficiency, and in vitro drug release. Topics related with liposomal functionalization and effective targeting strategies were also addressed, as well as stability and some limitations of liposomes. Finally, this review intends to explore the current market liposomes used as a drug delivery system in different therapeutic applications.
  • Editor: Netherlands: Elsevier B.V
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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