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The Influence of Antibiotics and Antitumor Agents on the Relaxation Activity of Pisum sativum Leaf Chloroplast Topoisomerase I

Zagariya, A.M. ; Sitailo, L.A.

Archives of biochemistry and biophysics, 1995-06, Vol.320 (1), p.177-181 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
The Influence of Antibiotics and Antitumor Agents on the Relaxation Activity of Pisum sativum Leaf Chloroplast Topoisomerase I
Autor: Zagariya, A.M. ; Sitailo, L.A.
Assuntos: activador enzimatico ; activateur d' enzyme ; actividad enzimatica ; activite enzymatique ; adn ; Amiloride - pharmacology ; Amsacrine - pharmacology ; Anti-Bacterial Agents - pharmacology ; antibioticos ; antibiotics ; antibiotique ; Antineoplastic Agents - pharmacology ; Camptothecin - pharmacology ; chloroplaste ; chloroplasts ; Chloroplasts - enzymology ; cloroplasto ; dna ; DNA Topoisomerases, Type I - metabolism ; DNA, Plant - drug effects ; DNA, Plant - metabolism ; enzimas ; enzyme ; enzyme activators ; enzyme inhibitors ; enzymes ; enzymic activity ; Ethidium - pharmacology ; feuille ; Heparin - pharmacology ; hojas ; Indoles - pharmacology ; inhibidores de enzimas ; inhibiteur d' enzyme ; leaves ; Magnesium - pharmacology ; Nalidixic Acid - pharmacology ; Novobiocin - pharmacology ; pisum sativum ; Pisum sativum - enzymology ; Polyamines - pharmacology ; Topoisomerase I Inhibitors
É parte de: Archives of biochemistry and biophysics, 1995-06, Vol.320 (1), p.177-181
Notas: F60
F
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Descrição: DNA topoisomerase was isolated from pea leaf chloroplasts. The relaxation activity of this topoisomerase was Mg2+ dependent and sensitive to ethidium bromide and novobiocin, a gyrase inhibitor. Chloroplast topoisomerase (Topo I) was ATP independent, as shown by the characteristic gel distribution of topoisomers. Topoisomerase, compared with the known eucaryotic topoisomerase I, was not stimulated by polyamines as are spermidine, spermine, and cadaverine. Ethidium bromide, DAPI, heparin, nalidixic acid, and m-AMSA (but not camptothecin) were able to inhibit the relaxation activity of chloroplast topo I. Nalidixic acid, novobiocin, m-AMSA, camptothecin, and amiloride were tested for their effects on the topo-isomerase-catalyzed "cleavage complex" between DNA and chloroplast DNA topoisomerase I.
Editor: United States: Elsevier Inc
Idioma: Inglês

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The Influence of Antibiotics and Antitumor Agents on the Relaxation Activity of Pisum sativum Leaf Chloroplast Topoisomerase I

Zagariya, A.M. ; Sitailo, L.A.

United States: Elsevier Inc

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