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Intraoperative radiotherapy for brain metastases: first-stage results of a single-arm, open-label, phase 2 trial

de Castro, Douglas Guedes ; Sanematsu, Paulo Issamu ; Pellizzon, Antônio Cassio Assis ; Suzuki, Sérgio Hideki ; Fogaroli, Ricardo Cesar ; Dias, José Eduardo Souza ; Gondim, Guilherme Rocha Melo ; Estrada, Daniel Alvarez ; Silva, Maria Letícia Gobo ; Rassi, Marcio Saquy ; Chen, Michael Jenwei ; Giacomelli, Richard ; Ramos, Henderson ; Neto, Elson Santos ; Abrahão, Carolina Humeres ; Coelho, Tharcisio Machado ; Yu, Liao Shin ; de Queiroz Tannous, Cassio ; Calsavara, Vinicius Fernando ; Giordano, Frank Anton ; de Oliveira, Jean Gonçalves

Journal of neuro-oncology, 2023-03, Vol.162 (1), p.211-215 [Periódico revisado por pares]

New York: Springer US

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Título:
Intraoperative radiotherapy for brain metastases: first-stage results of a single-arm, open-label, phase 2 trial
Autor: de Castro, Douglas Guedes ; Sanematsu, Paulo Issamu ; Pellizzon, Antônio Cassio Assis ; Suzuki, Sérgio Hideki ; Fogaroli, Ricardo Cesar ; Dias, José Eduardo Souza ; Gondim, Guilherme Rocha Melo ; Estrada, Daniel Alvarez ; Silva, Maria Letícia Gobo ; Rassi, Marcio Saquy ; Chen, Michael Jenwei ; Giacomelli, Richard ; Ramos, Henderson ; Neto, Elson Santos ; Abrahão, Carolina Humeres ; Coelho, Tharcisio Machado ; Yu, Liao Shin ; de Queiroz Tannous, Cassio ; Calsavara, Vinicius Fernando ; Giordano, Frank Anton ; de Oliveira, Jean Gonçalves
Assuntos: Adult ; Brain - pathology ; Brain cancer ; Brain Neoplasms - pathology ; Brain Neoplasms - radiotherapy ; Brain Neoplasms - surgery ; Case Study ; Disease control ; Humans ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Neuroimaging ; Neurology ; Neurosurgical Procedures ; Oncology ; Radiation therapy ; Radiosurgery ; Radiosurgery - adverse effects ; Radiosurgery - methods ; Retrospective Studies ; Treatment Outcome
É parte de: Journal of neuro-oncology, 2023-03, Vol.162 (1), p.211-215
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: Objective Focal stereotactic radiosurgery to the surgical cavity lowers local recurrence after resection of brain metastases (BM). To evaluate local control (LC) and brain disease control (BDC) after intraoperative radiotherapy (IORT) for resected BM. Methods Adult patients with completely resected single supratentorial BM were recruited and underwent IORT to the cavity with a prescribed dose of 18 Gy to 1 mm-depth. Primary endpoints were actuarial LC and BDC. Local failure (LF) and distant brain failure (DBF), with death as a competing risk, were estimated. Secondary endpoints were overall survival (OS) and incidence of radiation necrosis (RN). Simon’s two-stage design was used and estimated an accrual of 10 patients for the first-stage analysis and a LC higher than 63% to proceed to second stage. We report the final analysis of the first stage. Results Between June 2019 to November 2020, 10 patients were accrued. Median clinical and imaging FU was 11.2 and 9.7 months, respectively. Median LC was not reached and median BDC was 5 months. The 6-month and 12-month LC was 87.5%. The 6-month and 12-month BDC was 39% and 13%, respectively. Incidence of LF at 6 and 12 months was 10% and of DBF at 6 and 12 months was 50% and 70%, respectively. Median OS was not reached. The 6-month and 12-month OS was 80%. One patient had asymptomatic RN. Conclusion IORT for completely resected BM is associated with a potential high local control and low risk of RN, reaching the pre-specified criteria to proceed to second stage and warranting further studies.
Editor: New York: Springer US
Idioma: Inglês

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Intraoperative radiotherapy for brain metastases: first-stage results of a single-arm, open-label, phase 2 trial

New York: Springer US

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