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De-novo hepatocellular carcinoma after pediatric living donor liver transplantation

Torres-Landa, Samuel ; Muñoz-Abraham, Armando Salim ; Fortune, Brett E ; Gurung, Ananta ; Pollak, Jeffrey ; Emre, Sukru H ; Rodriguez-Davalos, Manuel I ; Schilsky, Michael L

World journal of hepatology, 2017-12, Vol.9 (36), p.1361-1366

United States: Baishideng Publishing Group Inc

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  • Título:
    De-novo hepatocellular carcinoma after pediatric living donor liver transplantation
  • Autor: Torres-Landa, Samuel ; Muñoz-Abraham, Armando Salim ; Fortune, Brett E ; Gurung, Ananta ; Pollak, Jeffrey ; Emre, Sukru H ; Rodriguez-Davalos, Manuel I ; Schilsky, Michael L
  • Assuntos: Case Report
  • É parte de: World journal of hepatology, 2017-12, Vol.9 (36), p.1361-1366
  • Notas: Telephone: +1-203-7856501 Fax: +1-203-7374033
    Correspondence to: Manuel I Rodriguez-Davalos, Associate Professor, Department of Surgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510, United States. rodriguezmi@me.com
    Author contributions: Torres-Landa S, Munoz-Abraham AS, Fortune BE, Emre SH, Rodriguez-Davalos MI, and Schilsky ML contributed with the case report design, collecting the data and writing the manuscript; Gurung A helped with the pathology reports, pathology images description and analysis of the data; Pollak J helped with the radiology reports and analysis of the data.
  • Descrição: De-novo malignancies carry an incidence ranging between 3%-26% after transplant and account for the second highest cause of post-transplant mortality behind cardiovascular disease. While the majority of de-novo malignancies after transplant usually consist of skin cancers, there has been an increasing rate of solid tumor cancers over the last 15 years. Although, recurrence of hepatocellular carcinoma(HCC) is well understood among patients transplanted for HCC, there are increasing reports of de-novo HCC in those transplanted for a non-HCC indication. The proposed pathophysiology for these cases has been mainly connected to the presence of advanced graft fibrosis or cirrhosis and always associated with the presence of hepatitis B or C virus. We report the first known case of de-novo HCC in a recipient, 14 years after a pediatric living related donor liver transplantation for end-stage liver disease due to biliary atresia without the presence of hepatitis B or C virus before and after transplant. We present this case report to increase the awareness of this phenomenon and address on the utility for screening and surveillance of hepatocellular carcinoma among these individuals. One recommendation is to use similar guidelines for screening, diagnosis, and treatment for HCC as those used for primary HCC in the pre-transplant patient, focusing on those recipients who have advanced fibrosis in the allograft, regardless of etiology.
  • Editor: United States: Baishideng Publishing Group Inc
  • Idioma: Inglês
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