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Evaluation of fentanyl disposition and effects in newborn piglets as an experimental model for human neonates

Rey-Santano, Carmen ; Mielgo, Victoria ; Valls-I-Soler, Adolfo ; Encinas, Esther ; Lukas, John C ; Vozmediano, Valvanera ; Suárez, Elena Rogers, Lynette K.

PloS one, 2014-03, Vol.9 (3), p.e90728 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Evaluation of fentanyl disposition and effects in newborn piglets as an experimental model for human neonates
Autor: Rey-Santano, Carmen ; Mielgo, Victoria ; Valls-I-Soler, Adolfo ; Encinas, Esther ; Lukas, John C ; Vozmediano, Valvanera ; Suárez, Elena
Rogers, Lynette K.
Assuntos: Analysis ; Anesthetics, Intravenous - administration & dosage ; Anesthetics, Intravenous - pharmacokinetics ; Anesthetics, Intravenous - pharmacology ; Animals ; Biology ; Brain ; Central nervous system depressants ; Female ; Fentanyl ; Fentanyl - administration & dosage ; Fentanyl - pharmacokinetics ; Fentanyl - pharmacology ; Heart beat ; Heart rate ; Heart Rate - drug effects ; Hemodynamics - drug effects ; Humans ; Infant, Newborn ; Male ; Mechanical ventilation ; Medicine ; Models, Animal ; Neonates ; Newborn babies ; Oxygenation ; Pharmacokinetics ; Pharmacology ; Plasma levels ; Respiration - drug effects ; Respiration, Artificial ; Swine ; Ventilation ; Veterinary Science
É parte de: PloS one, 2014-03, Vol.9 (3), p.e90728
Notas: Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: CRS VEM AVS ES JCL. Performed the experiments: CRS VEM EE. Analyzed the data: EE VEM ES CRS VEM. Contributed reagents/materials/analysis tools: AVS VV JCL. Wrote the paper: CRS VEM EE ES.
Descrição: Fentanyl is widely used off-label in NICU. Our aim was to investigate its cerebral, cardiovascular and pulmonary effects as well as pharmacokinetics in an experimental model for neonates. Fentanyl (5 µg/kg bolus immediately followed by a 90 minute infusion of 3 µg/kg/h) was administered to six mechanically ventilated newborn piglets. Cardiovascular, ventilation, pulmonary and oxygenation indexes as well as brain activity were monitored from T = 0 up to the end of experiments (T = 225-300 min). Also plasma samples for quantification of fentanyl were drawn. A "reliable degree of sedation" was observed up to T = 210-240 min, consistent with the selected dosing regimen and the observed fentanyl plasma levels. Unlike cardiovascular parameters, which were unmodified except for an increasing trend in heart rate, some of the ventilation and oxygenation indexes as well as brain activity were significantly altered. The pulmonary and brain effects of fentanyl were mostly recovered from T = 210 min to the end of experiment. The newborn piglet was shown to be a suitable experimental model for studying fentanyl disposition as well as respiratory and cardiovascular effects in human neonates. Therefore, it could be extremely useful for further investigating the drug behaviour under pathophysiological conditions.
Editor: United States: Public Library of Science
Idioma: Inglês

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Evaluation of fentanyl disposition and effects in newborn piglets as an experimental model for human neonates

Rey-Santano, Carmen ; Mielgo, Victoria ; Valls-I-Soler, Adolfo ; Encinas, Esther ; Lukas, John C ; Vozmediano, Valvanera ; Suárez, Elena Rogers, Lynette K.

United States: Public Library of Science

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