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The NIMH Research Domain Criteria Initiative: Background, Issues, and Pragmatics

Kozak, Michael J. ; Cuthbert, Bruce N.

Psychophysiology, 2016-03, Vol.53 (3), p.286-297 [Periódico revisado por pares]

United States: Blackwell Publishing Ltd

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  • Título:
    The NIMH Research Domain Criteria Initiative: Background, Issues, and Pragmatics
  • Autor: Kozak, Michael J. ; Cuthbert, Bruce N.
  • Assuntos: Biomarkers ; Biometrics ; Diagnostic and Statistical Manual ; Humans ; Hypothetical constructs ; Mental Disorders - diagnosis ; Mental Disorders - psychology ; National Institute of Mental Health ; National Institute of Mental Health (U.S.) ; Neuropsychology ; Psychiatry ; Psychometrics ; Psychopathology ; Psychopathology - methods ; Research Domain Criteria ; United States
  • É parte de: Psychophysiology, 2016-03, Vol.53 (3), p.286-297
  • Notas: istex:8B5789216ABAE128D56659A463B2CB79CCA8C8C1
    ArticleID:PSYP12518
    ark:/67375/WNG-4GJ2P5CJ-J
    Drs. Kozak and Cuthbert report no biomedical financial interests or potential conflicts of interest.
    The members of the NIMH RDoC workgroup are Bruce Cuthbert (chair), Marjorie Garvey, Rebecca Steiner Garcia, Marlene Guzman, Robert Heinssen, Arina Kadam, Michael Kozak, Sarah Morris, Daniel Pine, Kevin Quinn, Charles Sanislow, Janine Simmons, Uma Vaidyanathan, and Philip Wang. External consultants are Deanna Barch, Will Carpenter, and Michael First. Lisa Alberts, Sarah Morris, Varda Shoham, and Kevin Quinn provided comments on earlier drafts of this manuscript.
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: This article describes the National Institute of Mental Health's Research Domain Criteria (RDoC) initiative. The description includes background, rationale, goals, and the way the initiative has been developed and organized. The central RDoC concepts are summarized and the current matrix of constructs that have been vetted by workshops of extramural scientists is depicted. A number of theoretical and methodological issues that can arise in connection with the nature of RDoC constructs are highlighted: subjectivism and heterophenomenology, desynchrony and theoretical neutrality among units of analysis, theoretical reductionism, endophenotypes, biomarkers, neural circuits, construct “grain size,” and analytic challenges. The importance of linking RDoC constructs to psychiatric clinical problems is discussed. Some pragmatics of incorporating RDoC concepts into applications for NIMH research funding are considered, including sampling design.
  • Editor: United States: Blackwell Publishing Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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