Idioma:

Risk Factors Associated With Graft Loss and Patient Survival After Kidney Transplantation

Harada, K.M ; Mandia-Sampaio, E.L ; de Sandes-Freitas, T.V ; Felipe, C.R ; Park, S.I ; Pinheiro-Machado, P.G ; Garcia, R ; Tedesco-Silva, H ; Medina-Pestana, J.O

Transplantation proceedings, 2009-11, Vol.41 (9), p.3667-3670 [Periódico revisado por pares]

Amsterdam: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Risk Factors Associated With Graft Loss and Patient Survival After Kidney Transplantation
Autor: Harada, K.M ; Mandia-Sampaio, E.L ; de Sandes-Freitas, T.V ; Felipe, C.R ; Park, S.I ; Pinheiro-Machado, P.G ; Garcia, R ; Tedesco-Silva, H ; Medina-Pestana, J.O
Assuntos: Adult ; Biological and medical sciences ; Body Mass Index ; Continental Population Groups ; Epidemiology ; Ethnic Groups ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; General aspects ; Graft Rejection - epidemiology ; Humans ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - surgery ; Kidney Transplantation - adverse effects ; Kidney Transplantation - mortality ; Kidney Transplantation - physiology ; Living Donors - statistics & numerical data ; Male ; Medical sciences ; Patient Selection ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Retrospective Studies ; Risk Factors ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Survival Rate ; Survivors ; Time Factors ; Tissue, organ and graft immunology ; Treatment Failure
É parte de: Transplantation proceedings, 2009-11, Vol.41 (9), p.3667-3670
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Abstract Objective To evaluate the influence of traditional risk factors on major kidney transplantation outcome. Patients and Methods Data from kidney transplantation procedures performed between 2003 and 2006 were retrospectively analyzed for the influence of traditional risk factors on transplantation outcome. Of 2364 transplants, 67% were from living donors, 27% were from donors who met standard criteria, and 6% were from donor who met expanded criteria. Two hundred thirty-nine procedures (10%) were performed in pediatric patients. Immunosuppression was selected on the basis of subgroup population. Results At 1 year posttransplantation, cumulative freedom from a treated acute rejection episode (ARE) was 76.7%, with no difference between black vs nonblack recipients (75.0% vs 73.4%; P = .79). At 2 years, survival for patients (95.3% vs 88.3% vs 82.1%; P < .001) and grafts 92.3% vs 80.3% vs 70.9%; P < .001) was better in recipients of living donor grafts compared with donors who met standard or expanded criteria, respectively. Moreover, graft survival was poorer in black vs nonblack patients (83.6% vs 88.7%; P < .05) because of high mortality (13% vs 7%; P <.001). Risk factors associated with death included cadaveric donor organ (odds ratio [OR], 2.4) and black race (OR, 1.8), and risk factors associated with graft loss included cadaveric donor organ (OR, 2.1), extended-criteria criteria donor organ (OR, 2.0), delayed graft function (OR, 1.8), and any ARE (OR, 3.5). At 6 months posttransplantation, risk factors associated with death included cadaveric donor organ (OR, 2.5) or ARE (OR, 2.4), and risk factors associated with graft loss included cadaveric donor organ (OR, 2.0), extended-criteria donor organ (OR, 2.6), ARE (OR, 9.5), and impaired graft function (creatinine concentration >1.5 mg/dL; OR, 2.1). Conclusion Traditional risk factors are still associated with transplantation outcome. Poorer graft survival in black vs nonblack recipients was due to higher mortality rather than graft loss.
Editor: Amsterdam: Elsevier Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 8 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Risk Factors Associated With Graft Loss and Patient Survival After Kidney Transplantation

Harada, K.M ; Mandia-Sampaio, E.L ; de Sandes-Freitas, T.V ; Felipe, C.R ; Park, S.I ; Pinheiro-Machado, P.G ; Garcia, R ; Tedesco-Silva, H ; Medina-Pestana, J.O

Amsterdam: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.