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Poorly controlled type 2 diabetes mellitus is associated with a decreased risk of incident gout: a population-based case-control study

Bruderer, Saskia G ; Bodmer, Michael ; Jick, Susan S ; Meier, Christoph R

Annals of the rheumatic diseases, 2015-09, Vol.74 (9), p.1651-1658 [Periódico revisado por pares]

England: BMJ Publishing Group LTD

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Título:
Poorly controlled type 2 diabetes mellitus is associated with a decreased risk of incident gout: a population-based case-control study
Autor: Bruderer, Saskia G ; Bodmer, Michael ; Jick, Susan S ; Meier, Christoph R
Assuntos: Age ; Aged ; Aged, 80 and over ; Alcohol ; Bias ; Body mass index ; Case-Control Studies ; Diabetes ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - metabolism ; Female ; Glycated Hemoglobin A - metabolism ; Gout - epidemiology ; Health risk assessment ; HIV ; Human immunodeficiency virus ; Humans ; Hypertension ; Hypoglycemic Agents - therapeutic use ; Insulin - therapeutic use ; Logistic Models ; Male ; Metformin - therapeutic use ; Middle Aged ; Odds Ratio ; Patients ; Population ; Retrospective Studies ; Rheumatoid arthritis ; Risk factors ; Severity of Illness Index ; Skin cancer ; Studies ; Sulfonylurea Compounds - therapeutic use ; Time Factors ; Treatment Outcome ; United Kingdom - epidemiology
É parte de: Annals of the rheumatic diseases, 2015-09, Vol.74 (9), p.1651-1658
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: ObjectiveThe aim of this study was to explore the risk of incident gout in patients with type 2 diabetes mellitus (T2DM) in association with diabetes duration, diabetes severity and antidiabetic drug treatment.MethodsWe conducted a case-control study in patients with T2DM using the UK-based Clinical Practice Research Datalink (CPRD). We identified case patients aged ≥18 years with an incident diagnosis of gout between 1990 and 2012. We matched to each case patient one gout-free control patient. We used conditional logistic regression analysis to calculate adjusted ORs (adj. ORs) with 95% CIs and adjusted our analyses for important potential confounders.ResultsThe study encompassed 7536 T2DM cases with a first-time diagnosis of gout. Compared to a diabetes duration <1 year, prolonged diabetes duration (1–3, 3–6, 7–9 and ≥10 years) was associated with decreased adj. ORs of 0.91 (95% CI 0.79 to 1.04), 0.76 (95% CI 0.67 to 0.86), 0.70 (95% CI 0.61 to 0.86), and 0.58 (95% CI 0.51 to 0.66), respectively. Compared to a reference A1C level of <7%, the risk estimates of increasing A1C levels (7.0–7.9, 8.0–8.9 and ≥9%) steadily decreased with adj. ORs of 0.79 (95% CI 0.72 to 0.86), 0.63 (95% CI 0.55 to 0.72), and 0.46 (95% CI 0.40 to 0.53), respectively. Neither use of insulin, metformin, nor sulfonylureas was associated with an altered risk of incident gout.ConclusionsIncreased A1C levels, but not use of antidiabetic drugs, was associated with a decreased risk of incident gout among patients with T2DM.
Editor: England: BMJ Publishing Group LTD
Idioma: Inglês

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Poorly controlled type 2 diabetes mellitus is associated with a decreased risk of incident gout: a population-based case-control study

Bruderer, Saskia G ; Bodmer, Michael ; Jick, Susan S ; Meier, Christoph R

England: BMJ Publishing Group LTD

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