skip to main content
Idioma:

Tuning inflammation response via adjusting microstructure of hydroxyapatite and biomolecules modification

Pang, Shumin ; Li, Xia ; Wu, Dongwei ; Li, Hong ; Wang, Xiupeng

Colloids and surfaces, B, Biointerfaces, 2019-05, Vol.177, p.496-505 [Periódico revisado por pares]

Netherlands: Elsevier B.V

Texto completo disponível

Citações Citado por
  • Título:
    Tuning inflammation response via adjusting microstructure of hydroxyapatite and biomolecules modification
  • Autor: Pang, Shumin ; Li, Xia ; Wu, Dongwei ; Li, Hong ; Wang, Xiupeng
  • Assuntos: Cytokines ; Hydroxyapatite ; Icariin ; Inflammatory ; Kaempferol
  • É parte de: Colloids and surfaces, B, Biointerfaces, 2019-05, Vol.177, p.496-505
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: [Display omitted] •Rod-like and Flake-like HAP particles were synthesized.•With different drug loading capacity and internalization.•HAP-ICA (Icarrin) and HAP-kaempferol have good drug release and cytocompatibility.•HAP-ICA and HAP-Kaempferol inhibited the secretion of inflammatory cytokines.•Caspase and p38 MAPK pathways were involved in inflammation regulation. Excellent biocompatibility and inflammatory regulation ability are essential to bone repair materials. Herein, Rod-like HAP with a diameter of 0.1 μm and Flake-like HAP with a width of 0.5–1 μm were synthesized by hydrothermal method, and then combined with two kinds of biomolecules, Icariin and Kaempferol. Two kinds of HAPs have similar crystal structure, but different zeta potentials and specific surface area. Rod-like HAP possesses stronger loading capacity and internalization efficiency than Flake-like one. in vitro inflammation assay reveals that HAP particles up-regulate the expression of IL-1β, TNF-α, IL-6, IL-10, IFN-γ and IL-2 cytokines. HAP particles loaded with Icariin or Kaempferol biomolecules up-regulate anti-inflammatory cytokines and down-regulate the expression of inflammatory cytokines.
  • Editor: Netherlands: Elsevier B.V
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.