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Relationship between disease severity, quality of life and health-care resource use in a cross-section of Australian patients with Crohn's disease

Gibson, Peter R ; Weston, Adèle R ; Shann, Amelia ; Florin, Timothy H J ; Lawrance, Ian C ; Macrae, Finlay A ; Radford-Smith, Graham

Journal of gastroenterology and hepatology, 2007-08, Vol.22 (8), p.1306-1312 [Periódico revisado por pares]

Melbourne, Australia: Blackwell Publishing Asia

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  • Título:
    Relationship between disease severity, quality of life and health-care resource use in a cross-section of Australian patients with Crohn's disease
  • Autor: Gibson, Peter R ; Weston, Adèle R ; Shann, Amelia ; Florin, Timothy H J ; Lawrance, Ian C ; Macrae, Finlay A ; Radford-Smith, Graham
  • Assuntos: Adult ; Australia ; Biological and medical sciences ; cost-utility ; Crohn Disease - economics ; Crohn Disease - pathology ; Crohn Disease - therapy ; Crohn's disease activity index ; Female ; fistula ; Gastroenterology. Liver. Pancreas. Abdomen ; Health Care Costs ; health economics ; Health Services - utilization ; Health Status ; Humans ; Male ; Medical sciences ; Other diseases. Semiology ; Quality of Life ; Severity of Illness Index ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surveys and Questionnaires
  • É parte de: Journal of gastroenterology and hepatology, 2007-08, Vol.22 (8), p.1306-1312
  • Notas: ArticleID:JGH4930
    istex:3AA5A07B8849ACFEFCF557B38BC961F568D84454
    ark:/67375/WNG-5Q9D16WK-8
    The authors have no competing interests with regard to the content of the manuscript. A. Shann was an employee of the sponsor. AR Weston was a paid consultant of the sponsor. PR Gibson, THJ Florin, IC Lawrance, FA Macrae, and G Radford‐Smith all have acted as consultants for the sponsor on an advisory board and have been investigators in clinical trials with the sponsor's product(s).
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Background and Aim:  New treatments for Crohn's disease are expensive and place economic strain upon health‐care systems, and ‘value‐for‐money’ needs to be confirmed. This study aimed to correlate disease severity with health‐related quality of life and with health‐care resource use, to allow evaluation of the cost effectiveness of these treatments. Methods:  A cross‐sectional, non‐interventional, pharmacoeconomics study was performed with patients completing questionnaires comprising demographic, disease and health‐care utilization questions, together with the disease‐specific Inflammatory Bowel Disease Questionnaire (IBDQ) and the Assessment of Quality of Life (AQoL) multi‐attribute utility instrument. The Crohn's Disease Activity Index (CDAI) was used to assess disease severity. Results:  143 patients with a broad range of disease severity (CDAI 36–446, fistulae 23%) were recruited from referral centers. Stepwise regression analyses demonstrated a negative correlation between disease severity and both IBDQ and AQoL (both P < 0.0001). Age, gender and years since diagnosis did not impact upon either of the quality‐of‐life outcomes. Mean utility score for non‐fistulizing patients with moderate–severe active disease (CDAI ≥ 220) was 0.45, mild disease (CDAI 150–219) was 0.68 and for remission (CDAI < 150) was 0.77. Health‐care resource utilization increased with increasing CDAI (P < 0.001), with hospital admissions being the largest component cost. Twenty‐seven percent of patients (mean age 38 year) received a government benefit, 51% primarily due to their Crohn's disease. Conclusion:  Crohn's disease severity correlates with poor quality of life. Utility scores determined will permit cost–utility analyses to be made in order to best allocate limited health resources.
  • Editor: Melbourne, Australia: Blackwell Publishing Asia
  • Idioma: Inglês
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