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Study on the Efficiency of Hard Gelatin Capsules Coating in a Spouted Bed

Oliveira, Helder V. A. ; Peixoto, Maria P. G. ; Freitas, Luis A. P.

Drying technology, 2005-09, Vol.23 (9-11), p.2039-2053 [Periódico revisado por pares]

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Título:
Study on the Efficiency of Hard Gelatin Capsules Coating in a Spouted Bed
Autor: Oliveira, Helder V. A. ; Peixoto, Maria P. G. ; Freitas, Luis A. P.
Assuntos: Fluid dynamics ; Methacrylic polymer ; Stability ; Suspension viscosity
É parte de: Drying technology, 2005-09, Vol.23 (9-11), p.2039-2053
Descrição: The aim of this work was to study the process of capsules coating in a lab-scale spouted bed. A conventional spouted bed (CSB) with 9.5 cm column diameter and 60° conical base was used in the experiments. The spouting fluid dynamics of capsules with different sizes were determined. In the equipment used only capsules size 03 (outer diameter: 5.82 cm; length: 15.9 mm) presented stable spouting. The effect of capsules load in the column, coating suspension viscosity, and coating time on the coating efficiency were studied in a factorial experimental design. Typical efficiencies for the process were found to be in the range of 69.54-84.88%. The efficiencies increased with bed load at 1% significance level, but were not affected by coating time and suspension viscosity. CBS is a promising method for the HGC coating that eliminates preliminary sealing steps.
Editor: Taylor & Francis Group
Idioma: Inglês

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