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Bone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model

Yi, Kyong Wook ; Mamillapalli, Ramanaiah ; Sahin, Cagdas ; Song, Jaeyen ; Tal, Reshef ; Taylor, Hugh S

Biology of reproduction, 2019-01, Vol.100 (1), p.61-70 [Periódico revisado por pares]

United States: Society for the Study of Reproduction

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Bone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model
Autor: Yi, Kyong Wook ; Mamillapalli, Ramanaiah ; Sahin, Cagdas ; Song, Jaeyen ; Tal, Reshef ; Taylor, Hugh S
Assuntos: Animals ; Bone marrow ; Bone Marrow Cells - physiology ; Bone Marrow Transplantation ; bone marrow-derived cells (BMDCs) ; Chemokine CXCL12 - pharmacology ; Chemokines ; CXCL12 ; Disease Models, Animal ; Embryo Implantation - drug effects ; Embryo Implantation - physiology ; Endometrium ; Endometrium - drug effects ; Endometrium - pathology ; Endometrium - physiology ; Female ; infertility ; Infertility, Female - etiology ; Infertility, Female - pathology ; Infertility, Female - therapy ; Male ; Mice ; Mice, Inbred C57BL ; Pregnancy ; Reproductive health ; thin endometrium ; Uterine Diseases - complications ; Uterine Diseases - pathology ; Uterine Diseases - therapy
É parte de: Biology of reproduction, 2019-01, Vol.100 (1), p.61-70
Descrição: Successful implantation and pregnancy is dependent on sufficient endometrial growth during each reproductive cycle. Here, we report the therapeutic effect of either bone marrow-derived cells (BMDCs) or the stem cell chemo-attractant C-X-C motif chemokine 12 (CXCL12) on endometrial receptivity in a murine ethanol induced thin endometrium model. Endometrial epithelial area was significantly increased in mice treated with BMDCs, CXCL12, or by co-treatment with both compared with PBS-treated controls. Ki-67 and CD31 immunoreactivity was significantly higher in mice treated with either BMDCs, CXCL12, or both. The mRNA expression levels of endometrial receptivity markers leukemia inhibitory factor, interleukin-1β, and integrin beta-3 were increased in mice treated with either BMDCs, CXCL12, or both. The mRNA levels of matrix metalloproteinase-2 and -9 were significantly decreased by BMDCs but not by CXCL12. Pregnancy rates and litter size were increased after either treatment. Both BMDCs and CXCL12 displayed a comparable efficacy on endometrial regeneration in mice with thin endometrium. Our findings indicate the potential therapeutic effects of BMDCs and CXCL12 on infertility related to thin endometrium. Bone marrow-derived cells and CXCL12 displayed a comparable efficacy on endometrial regeneration in mice with thin endometrium. Summary Sentence Bone marrow-derived cells and CXCL12 displayed a comparable efficacy on endometrial regeneration in mice with thin endometrium.
Editor: United States: Society for the Study of Reproduction
Idioma: Inglês

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Bone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model

Yi, Kyong Wook ; Mamillapalli, Ramanaiah ; Sahin, Cagdas ; Song, Jaeyen ; Tal, Reshef ; Taylor, Hugh S

United States: Society for the Study of Reproduction

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