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Effects of environmental enrichment and paradoxical sleep deprivation on open-field behavior of amphetamine-treated mice

Fukushiro, Daniela Fukue ; Calzavara, Mariana Bendlin ; Trombin, Thaís Fernanda ; Lopez, Giorgia Batlle ; Abílio, Vanessa Costhek ; Andersen, Monica Levy ; Tufik, Sergio ; Frussa-Filho, Roberto

Physiology & behavior, 2007-11, Vol.92 (4), p.773-779 [Periódico revisado por pares]

Cambridge: Elsevier Inc

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Título:
Effects of environmental enrichment and paradoxical sleep deprivation on open-field behavior of amphetamine-treated mice
Autor: Fukushiro, Daniela Fukue ; Calzavara, Mariana Bendlin ; Trombin, Thaís Fernanda ; Lopez, Giorgia Batlle ; Abílio, Vanessa Costhek ; Andersen, Monica Levy ; Tufik, Sergio ; Frussa-Filho, Roberto
Assuntos: Amphetamine ; Amphetamine - pharmacology ; Analysis of Variance ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; C57BL/6 mice ; Central Nervous System Stimulants - pharmacology ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Environment ; Environmental enrichment ; Euphoria - drug effects ; Euphoria - physiology ; Exploratory Behavior - drug effects ; Exploratory Behavior - physiology ; Fundamental and applied biological sciences. Psychology ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Motor Activity - drug effects ; Motor Activity - physiology ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Open-field behavior ; Paradoxical sleep deprivation ; Pharmacology. Drug treatments ; Psychiatry ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopharmacology ; Random Allocation ; Sleep Deprivation - physiopathology ; Statistics, Nonparametric
É parte de: Physiology & behavior, 2007-11, Vol.92 (4), p.773-779
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Descrição: Abstract Background Environmental enrichment or paradoxical sleep deprivation (PSD) has been shown to modify some responses elicited by drugs of abuse. The aims of the present study were to examine the effects of environmental enrichment and PSD, conducted separately or in association, on open-field behavior elicited by amphetamine (AMP) in mice. Methods Male C57BL/6 mice were randomly assigned to live in either an enriched environmental condition (EC) or a standard environmental condition (SC) for 12 months since weaning. Some of the EC and SC mice were sleep deprived for 48 h, while others were maintained in their home-cages. Immediately after PSD or home-cage stay, the animals received an ip injection of saline, 2.5 mg/kg AMP or 5.0 mg/kg AMP. Fifteen minutes later, their open-field behavior was quantified. Results Whereas PSD enhanced total and peripheral locomotor activity of acutely AMP-treated mice, environmental enrichment presented only a trend toward enhancement. When PSD and environmental enrichment were combined, an increase in the total and peripheral locomotion frequencies of AMP-treated animals, similar to that observed after PSD, was revealed. In addition, PSD, environmental enrichment or their combination did not modify the effects of AMP on the other open-field behavioral parameters that were analyzed. Conclusion The present findings demonstrate that some (but not all) of the behavioral effects caused by AMP acute administration can be similarly and specifically enhanced by both environmental enrichment and PSD in C57BL/6 mice.
Editor: Cambridge: Elsevier Inc
Idioma: Inglês

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Effects of environmental enrichment and paradoxical sleep deprivation on open-field behavior of amphetamine-treated mice

Fukushiro, Daniela Fukue ; Calzavara, Mariana Bendlin ; Trombin, Thaís Fernanda ; Lopez, Giorgia Batlle ; Abílio, Vanessa Costhek ; Andersen, Monica Levy ; Tufik, Sergio ; Frussa-Filho, Roberto

Cambridge: Elsevier Inc

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