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Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans

King, RA ; Bursill, DB

The American journal of clinical nutrition, 1998-05, Vol.67 (5), p.867-872 [Periódico revisado por pares]

Bethesda, MD: Elsevier Inc

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Título:
Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans
Autor: King, RA ; Bursill, DB
Assuntos: Adult ; Antineoplastic Agents - blood ; Antineoplastic Agents - pharmacokinetics ; Antineoplastic Agents - urine ; Biological and medical sciences ; BLOOD PLASMA ; Chromans - blood ; Chromans - pharmacokinetics ; Chromans - urine ; DIET ; DIETA ; Equol ; Estrogens, Non-Steroidal - blood ; Estrogens, Non-Steroidal - pharmacokinetics ; Estrogens, Non-Steroidal - urine ; EXCRECION ; EXCRETION ; FARMACOLOGIA ; Feeding. Feeding behavior ; FLAVONOIDE ; FLAVONOIDES ; FLAVONOIDS ; Flour ; Fundamental and applied biological sciences. Psychology ; Genistein - blood ; Genistein - pharmacokinetics ; Genistein - urine ; HOMBRES ; HOMME ; Humans ; Isoflavones - blood ; Isoflavones - pharmacokinetics ; Isoflavones - urine ; Male ; MEN ; Metabolism ; Middle Aged ; Monoamine Oxidase Inhibitors - blood ; Monoamine Oxidase Inhibitors - pharmacokinetics ; Monoamine Oxidase Inhibitors - urine ; Nutrition ; ORINA ; PHARMACOLOGIE ; PHARMACOLOGY ; PLASMA SANGUIN ; PLASMA SANGUINEO ; Postprandial Period ; REGIME ALIMENTAIRE ; SOYBEAN FLOUR ; SOYBEAN MEAL ; Soybean Proteins - administration & dosage ; Soybean Proteins - pharmacology ; Soybeans ; Time Factors ; TORTAS DE SOJA ; TOURTEAU DE SOJA ; URINE ; Vertebrates: anatomy and physiology, studies on body, several organs or systems
É parte de: The American journal of clinical nutrition, 1998-05, Vol.67 (5), p.867-872
Notas: S20
S30
1997094092
Descrição: The aim of this study was to determine the pharmacokinetics and urinary excretion patterns of the soy isoflavones daidzein and genistein in humans. Six healthy men with a mean age of 37 y and a mean body mass index (in kg/m2) of 24 consumed a soybean flour-based meal on two occasions approximately 6 d apart. Blood samples and total urine were collected at intervals for the measurement of daidzein and genistein with HPLC. Isoflavone concentrations rose slowly and reached maximum values of 3.14 +/- 0.36 micromol/L at 7.42 +/- 0.74 h for daidzein and 4.09 +/- 0.94 micromol/L at 8.42 +/- 0.69 h for genistein. Elimination half-lives were 4.7 +/- 1.1 and 5.7 +/- 1.3 h for daidzein and genistein, respectively. The slow increase in plasma concentrations is consistent with the facilitation of absorption by hydrolysis in the small and large intestines of the glycosidic forms of the isoflavones present in soybean-containing foods to their corresponding aglycones. The rate of urinary excretion of daidzein was greater than that of genistein throughout the postmeal period, with mean recoveries of 62 +/- 6% and 22 +/- 4% (P < 0.001) for daidzein and genistein, respectively. However, the ratio of the areas under the plasma concentration versus time curves for genistein and daidzein was equal to the ratio of the concentrations of the respective isoflavones in the soy meal. It is concluded that the bioavailabilities of daidzein and genistein are similar, not withstanding the difference in urinary excretion.
Editor: Bethesda, MD: Elsevier Inc
Idioma: Inglês

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Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans

King, RA ; Bursill, DB

Bethesda, MD: Elsevier Inc

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