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Human papillomavirus in women infected with human immunodeficiency virus: association with viral load and lymphocyte count

Morais, Ana Cléa Cutrim Diniz de ; Ferreira, Alice de Sá ; Barbosa, Carla Déa Trindade ; Lima, Maria Fernanda Bezerra ; Fook, Karina Donato ; Carvalho, Mônika Machado de ; Muniz, Alessandra Costa de Sales ; Araújo, Deborah Rocha de ; Monteiro, Pablo de Matos ; Araújo, Maria José Abigail Mendes ; Monteiro, Sally Cristina Moutinho ; Lopes, Fernanda Ferreira

Revista do Instituto de Medicina Tropical de São Paulo, 2024-01, Vol.66, p.e36 [Periódico revisado por pares]

Instituto de Medicina Tropical de São Paulo

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  • Título:
    Human papillomavirus in women infected with human immunodeficiency virus: association with viral load and lymphocyte count
  • Autor: Morais, Ana Cléa Cutrim Diniz de ; Ferreira, Alice de Sá ; Barbosa, Carla Déa Trindade ; Lima, Maria Fernanda Bezerra ; Fook, Karina Donato ; Carvalho, Mônika Machado de ; Muniz, Alessandra Costa de Sales ; Araújo, Deborah Rocha de ; Monteiro, Pablo de Matos ; Araújo, Maria José Abigail Mendes ; Monteiro, Sally Cristina Moutinho ; Lopes, Fernanda Ferreira
  • Assuntos: Original ; TROPICAL MEDICINE
  • É parte de: Revista do Instituto de Medicina Tropical de São Paulo, 2024-01, Vol.66, p.e36
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Women living with human immunodeficiency virus are at an increased risk of developing cancers related to human papillomavirus (HPV). Thus, it is important to combine clinical assessments, serological screening, and HPV data for planning prevention policies. This study aimed to identify HPV and its specific types in the cervical, anal, and oral mucosa of HIV-seropositive women, associating it with viral load and lymphocyte count. Sociodemographic characteristics, health data (CD4+ and CD8+ T cell counts and viral load), and biological samples (cervical, anal, and oral) were collected from 86 HIV-positive women undergoing antiretroviral therapy. Data were classified according to the presence or absence of HPV-DNA, HPV-DNA presence at one or more anatomic sites, and level of oncogenic risk, considering low- and high-risk oncogenic HPV-DNA groups. The presence of HPV in the cervicovaginal site was 65.9%, 63.8% in anal canal, and 4.2% in oral mucosa. A viral load ≥75 HIV copies/mL was associated with the presence of HPV-DNA. There was an association between viral load and the low-risk HPV or high-risk HPV groups. We found a high prevalence of HPV infection in HIV-seropositive women, particularly in the cervical and anal mucosa, with viral load ≥75 HIV copies/mL being associated with HPV-DNA presence.Women living with human immunodeficiency virus are at an increased risk of developing cancers related to human papillomavirus (HPV). Thus, it is important to combine clinical assessments, serological screening, and HPV data for planning prevention policies. This study aimed to identify HPV and its specific types in the cervical, anal, and oral mucosa of HIV-seropositive women, associating it with viral load and lymphocyte count. Sociodemographic characteristics, health data (CD4+ and CD8+ T cell counts and viral load), and biological samples (cervical, anal, and oral) were collected from 86 HIV-positive women undergoing antiretroviral therapy. Data were classified according to the presence or absence of HPV-DNA, HPV-DNA presence at one or more anatomic sites, and level of oncogenic risk, considering low- and high-risk oncogenic HPV-DNA groups. The presence of HPV in the cervicovaginal site was 65.9%, 63.8% in anal canal, and 4.2% in oral mucosa. A viral load ≥75 HIV copies/mL was associated with the presence of HPV-DNA. There was an association between viral load and the low-risk HPV or high-risk HPV groups. We found a high prevalence of HPV infection in HIV-seropositive women, particularly in the cervical and anal mucosa, with viral load ≥75 HIV copies/mL being associated with HPV-DNA presence.
  • Editor: Instituto de Medicina Tropical de São Paulo
  • Idioma: Inglês;Português
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