Idioma:

Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1

Meier, S ; Mattheisen, M ; Vassos, E ; Strohmaier, J ; Treutlein, J ; Josef, F ; Breuer, R ; Degenhardt, F ; Mühleisen, T W ; Müller-Myhsok, B ; Steffens, M ; Schmael, C ; McMahon, F J ; Nöthen, M M ; Cichon, S ; Schulze, T G ; Rietschel, M ; Kelsoe, John R ; Greenwood, Tiffany A ; Nievergelt, Caroline M ; Barrett, Thomas B ; McKinney, Rebecca ; Shilling, Paul D ; Schork, Nicholas J ; Smith, Erin N ; Bloss, Cinnamon S ; Nurnberger, John ; Edenberg, Howard J ; Foroud, Tatiana ; Koller, Daniel L ; Gershon, Elliot S ; Liu, Chun-Yu ; Badner, Judith A ; Scheftner, William ; Lawson, William B ; Nwulia, Evaristus A ; Hipolito, Maria ; Coryell, William ; Rice, John ; Byerley, William ; McMahon, Francis ; Chen, David T W ; Schulze, Thomas G ; Berrettini, Wade ; Potash, James B ; Zandi, Peter P ; Mahon, Pamela B ; McInnis, Melvin ; Craig, David ; Szelinger, Szabolcs

Translational psychiatry, 2012-09, Vol.2 (9), p.e165-e165 [Periódico revisado por pares]

United States: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1
Autor: Meier, S ; Mattheisen, M ; Vassos, E ; Strohmaier, J ; Treutlein, J ; Josef, F ; Breuer, R ; Degenhardt, F ; Mühleisen, T W ; Müller-Myhsok, B ; Steffens, M ; Schmael, C ; McMahon, F J ; Nöthen, M M ; Cichon, S ; Schulze, T G ; Rietschel, M ; Kelsoe, John R ; Greenwood, Tiffany A ; Nievergelt, Caroline M ; Barrett, Thomas B ; McKinney, Rebecca ; Shilling, Paul D ; Schork, Nicholas J ; Smith, Erin N ; Bloss, Cinnamon S ; Nurnberger, John ; Edenberg, Howard J ; Foroud, Tatiana ; Koller, Daniel L ; Gershon, Elliot S ; Liu, Chun-Yu ; Badner, Judith A ; Scheftner, William ; Lawson, William B ; Nwulia, Evaristus A ; Hipolito, Maria ; Coryell, William ; Rice, John ; Byerley, William ; McMahon, Francis ; Chen, David T W ; Schulze, Thomas G ; Berrettini, Wade ; Potash, James B ; Zandi, Peter P ; Mahon, Pamela B ; McInnis, Melvin ; Craig, David ; Szelinger, Szabolcs
Assuntos: Adult ; Alleles ; Bipolar Disorder - diagnosis ; Bipolar Disorder - genetics ; Bipolar Disorder - psychology ; Case-Control Studies ; Delusions - genetics ; Factor Analysis, Statistical ; Female ; Genome-Wide Association Study ; Glucose Transporter Type 2 - genetics ; Humans ; Male ; Middle Aged ; Original
É parte de: Translational psychiatry, 2012-09, Vol.2 (9), p.e165-e165
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work.
A full list of authors is provided in the Appendix.
Descrição: Research suggests that clinical symptom dimensions may be more useful in delineating the genetics of bipolar disorder (BD) than standard diagnostic models. To date, no study has applied this concept to data from genome-wide association studies (GWAS). We performed a GWAS of factor dimensions in 927 clinically well-characterized BD patients of German ancestry. Rs9875793, which is located in an intergenic region of 3q26.1 and in the vicinity of the solute carrier family 2 (facilitated glucose transporter), member 2 gene (SLC2A2), was significantly associated with the factor analysis-derived dimension 'negative mood delusions' (n=927; P=4.65 × 10(-8), odds ratio (OR)=2.66). This dimension was comprised of the symptoms delusions of poverty, delusions of guilt and nihilistic delusions. In case-control analyses, significant association with the G allele of rs9875793 was only observed in the subgroup of BD patients who displayed symptoms of 'negative mood delusions' (allelic χ(2) model: P(G)=0.0001, OR=1.92; item present, n=89). Further support for the hypothesis that rs9875793 is associated with BD in patients displaying 'negative mood delusions' symptom, such as delusions of guilt, was obtained from an European American sample (GAIN/TGEN), which included 1247 BD patients and 1434 controls (P(EA)=0.028, OR=1.27).
Editor: United States: Nature Publishing Group
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1

United States: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.