Idioma:

Delayed postprandial TAG peak after intake of SFA compared with PUFA in subjects with and without familial hypercholesterolaemia: a randomised controlled trial

Øyri, Linn K. L. ; Hansson, Patrik ; Bogsrud, Martin P. ; Narverud, Ingunn ; Florholmen, Geir ; Leder, Lena ; Byfuglien, Marte G. ; Veierød, Marit B. ; Ulven, Stine M. ; Holven, Kirsten B.

British journal of nutrition, 2018-05, Vol.119 (10), p.1142-1150 [Periódico revisado por pares]

Cambridge, UK: Cambridge University Press

Texto completo disponível

Citações Citado por

Enviar para

Título:
Delayed postprandial TAG peak after intake of SFA compared with PUFA in subjects with and without familial hypercholesterolaemia: a randomised controlled trial
Autor: Øyri, Linn K. L. ; Hansson, Patrik ; Bogsrud, Martin P. ; Narverud, Ingunn ; Florholmen, Geir ; Leder, Lena ; Byfuglien, Marte G. ; Veierød, Marit B. ; Ulven, Stine M. ; Holven, Kirsten B.
Assuntos: Adult ; Alcohol ; Area Under Curve ; Atherosclerosis ; Blood & organ donations ; Body mass ; Body Mass Index ; Carbohydrates ; Cholesterol ; Clinical trials ; Cross-Over Studies ; Diet, High-Fat - adverse effects ; Double-Blind Method ; Evidence-based medicine ; Fatty acids ; Fatty Acids - administration & dosage ; Fatty Acids, Unsaturated - administration & dosage ; Female ; Health care ; Hospitals ; Human and Clinical Nutrition ; Humans ; Hyperlipoproteinemia Type II - blood ; Lipid metabolism ; Lipids ; Lipoproteins (very low density) ; Lipoproteins, VLDL - blood ; Low density lipoprotein ; Male ; Meals ; Metabolism ; Metabolites ; Mutation ; Nutrition research ; Polyunsaturated fatty acids ; Postprandial Period - physiology ; Proteins ; Randomization ; Smoking ; Time Factors ; Triglycerides - blood
É parte de: British journal of nutrition, 2018-05, Vol.119 (10), p.1142-1150
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
content type line 23
Descrição: Postprandial hypertriacylglycerolaemia is associated with an increased risk of developing CVD. How fat quality influences postprandial lipid response is scarcely explored in subjects with familial hypercholesterolaemia (FH). The aim of this study was to investigate the postprandial response of TAG and lipid sub-classes after consumption of high-fat meals with different fat quality in subjects with FH compared with normolipidaemic controls. A randomised controlled double-blind cross-over study with two meals and two groups was performed. A total of thirteen hypercholesterolaemic subjects with FH who discontinued lipid-lowering treatment 4 weeks before and during the study, and fourteen normolipidaemic controls, were included. Subjects were aged 18–30 years and had a BMI of 18·5–30·0 kg/m2. Each meal consisted of a muffin containing 60 g (70 E%) of fat, either mainly SFA (40 E%) or PUFA (40 E%), eaten in a random order with a wash-out period of 3–5 weeks between the meals. Blood samples were collected at baseline (fasting) and 2, 4 and 6 h after intake of the meals. In both FH and control subjects, the level of TAG and the largest VLDL sub-classes peaked at 2 h after intake of PUFA and at 4 h after intake of SFA. No significant differences were found in TAG levels between meals or between groups (0·25≤P≤0·72). The distinct TAG peaks may reflect differences in the postprandial lipid metabolism after intake of fatty acids with different chain lengths and degrees of saturation. The clinical impact of these findings remains to be determined.
Editor: Cambridge, UK: Cambridge University Press
Idioma: Inglês;Norueguês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Delayed postprandial TAG peak after intake of SFA compared with PUFA in subjects with and without familial hypercholesterolaemia: a randomised controlled trial

Øyri, Linn K. L. ; Hansson, Patrik ; Bogsrud, Martin P. ; Narverud, Ingunn ; Florholmen, Geir ; Leder, Lena ; Byfuglien, Marte G. ; Veierød, Marit B. ; Ulven, Stine M. ; Holven, Kirsten B.

Cambridge, UK: Cambridge University Press

Buscando em bases de dados remotas. Favor aguardar.