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Identification of (+)-Erythro-Mefloquine as an Active Enantiomer with Greater Efficacy than Mefloquine against Mycobacterium avium Infection in Mice

BERMUDEZ, Luiz E ; INDERLIED, Clark B ; YOUNG, Lowell S ; KOLONOSKI, Peter ; CHEE, Christopher B ; ARALAR, Priscilla ; PETROFSKY, Mary ; PARMAN, Toufan ; GREEN, Carol E ; LEWIN, Anita H ; ELLIS, William Y

Antimicrobial Agents and Chemotherapy, 2012-08, Vol.56 (8), p.4202-4206 [Periódico revisado por pares]

Washington, DC: American Society for Microbiology

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Título:
Identification of (+)-Erythro-Mefloquine as an Active Enantiomer with Greater Efficacy than Mefloquine against Mycobacterium avium Infection in Mice
Autor: BERMUDEZ, Luiz E ; INDERLIED, Clark B ; YOUNG, Lowell S ; KOLONOSKI, Peter ; CHEE, Christopher B ; ARALAR, Priscilla ; PETROFSKY, Mary ; PARMAN, Toufan ; GREEN, Carol E ; LEWIN, Anita H ; ELLIS, William Y
Assuntos: Animals ; Anti-Bacterial Agents ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial diseases ; Bacterial Load - drug effects ; Biological and medical sciences ; Experimental Therapeutics ; Female ; Human bacterial diseases ; Humans ; Infectious diseases ; Liver - microbiology ; Medical sciences ; Mefloquine ; Mefloquine - analogs & derivatives ; Mefloquine - blood ; Mefloquine - pharmacology ; Mefloquine - therapeutic use ; Mice ; Mice, Inbred C57BL ; Microbial Sensitivity Tests ; Mycobacterium avium Complex ; Mycobacterium avium Complex - drug effects ; Mycobacterium avium Complex - isolation & purification ; Mycobacterium avium-intracellulare Infection ; Mycobacterium avium-intracellulare Infection - drug therapy ; Mycobacterium avium-intracellulare Infection - microbiology ; Pharmacology. Drug treatments ; Spleen - microbiology ; Stereoisomerism ; Tuberculosis and atypical mycobacterial infections
É parte de: Antimicrobial Agents and Chemotherapy, 2012-08, Vol.56 (8), p.4202-4206
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Editor: Washington, DC: American Society for Microbiology
Idioma: Inglês

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Identification of (+)-Erythro-Mefloquine as an Active Enantiomer with Greater Efficacy than Mefloquine against Mycobacterium avium Infection in Mice

BERMUDEZ, Luiz E ; INDERLIED, Clark B ; YOUNG, Lowell S ; KOLONOSKI, Peter ; CHEE, Christopher B ; ARALAR, Priscilla ; PETROFSKY, Mary ; PARMAN, Toufan ; GREEN, Carol E ; LEWIN, Anita H ; ELLIS, William Y

Washington, DC: American Society for Microbiology

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