Idioma:

Progress, Innovation and Regulatory Science in Drug Development: The Politics of International Standard-Setting

Abraham, John ; Reed, Tim

Social studies of science, 2002-06, Vol.32 (3), p.337-369 [Periódico revisado por pares]

London: Sage Publications

Texto completo disponível

Citações Citado por

Enviar para

Título:
Progress, Innovation and Regulatory Science in Drug Development: The Politics of International Standard-Setting
Autor: Abraham, John ; Reed, Tim
Assuntos: 20th century ; Administrative agencies ; Biology ; Carcinogenicity ; Discourse ; Dosage ; Drug Industry - history ; Drug regulation ; Drugs ; History of science and technology ; History, 20th Century ; Industrial regulation ; Innovation ; International Cooperation - history ; Life sciences ; Medications ; Medicine; surgery; pharmacy ; Pharmaceutical industry ; Pharmaceutical preparations ; Pharmaceuticals ; Pharmacology - history ; Pharmacy ; Politics ; Public Health ; Reference Standards ; Regulation ; Risk ; Risk Assessment ; Risk Assessment - history ; Rodents ; Science and technology ; Technological innovation ; Testing ; Tests ; Therapeutics ; Toxicology ; Toxicology - history
É parte de: Social studies of science, 2002-06, Vol.32 (3), p.337-369
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Descrição: This paper examines international standard-setting in the toxicology of pharmaceuticals during the 1990s, which has involved both the pharmaceutical industry and regulatory agencies in an organization known as the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The analysis shows that the relationships between innovation, regulatory science and 'progress' may be more complex and controversial than is often assumed. An assessment of the ICH's claims about the implications of 'technical' harmonization of drug-testing standards for the maintenance of drug safety, via toxicological testing, and the delivery of therapeutic progress, via innovation, is presented. By demonstrating that there is not a technoscientific validity for these claims, it is argued that, within the ICH, a discourse of technological innovation and scientific progress has been used by regulatory agencies and prominent parts of the transnational pharmaceutical industry to legitimize the lowering and loosening of toxicological standards for drug testing. The mobilization and acceptance of this discourse are shown to be pivotal to the ICH's transformation of reductions in safety standards, which are apparently against the interests of patients and public health, into supposed therapeutic benefits derived from promises of greater access to more innovative drug products. The evidence suggests that it is highly implausible that these reductions in the standards of regulatory toxicology are consistent with therapeutic progress for patients, and highlights a worrying aspect embedded in the 'technical trajectories' of regulatory science.
Editor: London: Sage Publications
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 4 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Progress, Innovation and Regulatory Science in Drug Development: The Politics of International Standard-Setting

Abraham, John ; Reed, Tim

London: Sage Publications

Buscando em bases de dados remotas. Favor aguardar.