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Genetic Determinants of High-Level Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus

Pardos de la Gandara, Maria ; Borges, Vitor ; Chung, Marilyn ; Milheiriço, Catarina ; Gomes, João Paulo ; de Lencastre, Herminia ; Tomasz, Alexander

Antimicrobial agents and chemotherapy, 2018-06, Vol.62 (6), p.e00206-18 [Periódico revisado por pares]

United States: American Society for Microbiology

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Título:
Genetic Determinants of High-Level Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus
Autor: Pardos de la Gandara, Maria ; Borges, Vitor ; Chung, Marilyn ; Milheiriço, Catarina ; Gomes, João Paulo ; de Lencastre, Herminia ; Tomasz, Alexander
Assuntos: Anti-Bacterial Agents ; Anti-Bacterial Agents - pharmacology ; Bacterial Proteins ; Bacterial Proteins - genetics ; Bacteriology ; Biochemistry, Molecular Biology ; Denmark ; Genomics ; Guanine ; Guanine - metabolism ; Humans ; Life Sciences ; Mechanisms of Resistance ; Methicillin Resistance ; Methicillin Resistance - genetics ; Methicillin-Resistant Staphylococcus aureus ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Methicillin-Resistant Staphylococcus aureus - genetics ; Methicillin-Resistant Staphylococcus aureus - isolation & purification ; Microbial Sensitivity Tests ; Microbiology and Parasitology ; Molecular biology ; Oxacillin ; Oxacillin - pharmacology ; Penicillin-Binding Proteins ; Penicillin-Binding Proteins - genetics ; United Kingdom ; Whole Genome Sequencing
É parte de: Antimicrobial agents and chemotherapy, 2018-06, Vol.62 (6), p.e00206-18
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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PMCID: PMC5971597
M.P.D.L.G. and V.B. contributed equally to the manuscript.
Present address: Maria Pardos de la Gandara, Institut Pasteur, Centre National de Référence des E. coli, Salmonella et Shigella, Paris, France.
Citation Pardos de la Gandara M, Borges V, Chung M, Milheiriço C, Gomes JP, de Lencastre H, Tomasz A. 2018. Genetic determinants of high-level oxacillin resistance in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 62:e00206-18. https://doi.org/10.1128/AAC.00206-18.
Descrição: Methicillin-resistant (MRSA) strains carry either a - or a -mediated mechanism of resistance to beta-lactam antibiotics, and the phenotypic expression of resistance shows extensive strain-to-strain variation. In recent communications, we identified the genetic determinants associated with the stringent stress response that play a major role in the antibiotic resistant phenotype of the historically earliest "archaic" clone of MRSA and in the -carrying MRSA strain LGA251. Here, we sought to test whether or not the same genetic determinants also contribute to the resistant phenotype of highly and homogeneously resistant (H*R) derivatives of a major contemporary MRSA clone, USA300. We found that the resistance phenotype was linked to six genes ( , , , , , and ), which were most frequently targeted among the analyzed 20 H*R strains (one mutation per clone in 19 of the 20 H*R strains). Besides the strong parallels with our previous findings (five of the six genes matched), all but one of the repeatedly targeted genes were found to be linked to guanine metabolism, pointing to the key role that this pathway plays in defining the level of antibiotic resistance independent of the clonal type of MRSA.
Editor: United States: American Society for Microbiology
Idioma: Inglês

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Genetic Determinants of High-Level Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus

Pardos de la Gandara, Maria ; Borges, Vitor ; Chung, Marilyn ; Milheiriço, Catarina ; Gomes, João Paulo ; de Lencastre, Herminia ; Tomasz, Alexander

United States: American Society for Microbiology

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