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Engineering Stem Cell
Self
-
organization
to Build Better Organoids
Brassard, Jonathan A. ; Lutolf, Matthias P.
Cell stem cell, 2019-06, Vol.24 (6), p.860-876
[Periódico revisado por pares]
United States: Elsevier Inc
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Título:
Engineering Stem Cell
Self
-
organization
to Build Better Organoids
Autor:
Brassard, Jonathan A.
;
Lutolf, Matthias P.
Assuntos:
biofabrication
;
biomaterial
;
extracellular matrix
;
morphogenesis
;
organoid
;
patterning
;
self
-
organization
;
stem cell
;
symmetry breaking
;
tissue engineering
É parte de:
Cell stem cell, 2019-06, Vol.24 (6), p.860-876
Notas:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição:
Organoids form through
self
-
organization
processes in which initially homogeneous populations of stem cells spontaneously break symmetry and undergo in-vivo-like pattern formation and morphogenesis, though the processes controlling this are poorly characterized. While these in vitro
self
-organized tissues far exceed the microscopic and functional complexity obtained by current tissue engineering technologies, they are non-physiological in shape and size and have limited function and lifespan. Here, we discuss how engineering efforts for guiding stem-cell-based development at multiple stages can form the basis for the assembly of highly complex and rationally designed
self
-organizing multicellular systems with increased robustness and physiological relevance. Organoids form through
self
-
organization
processes in which initially homogeneous populations of stem cells spontaneously break symmetry and undergo in-vivo-like pattern formation and morphogenesis, though the processes controlling this are poorly characterized. While these in vitro self-organized tissues far exceed the microscopic and functional complexity obtained by current tissue engineering technologies, they are non-physiological in shape and size and have limited function and lifespan. Here, we discuss how engineering efforts for guiding stem-cell-based development at multiple stages can form the basis for the assembly of highly complex and rationally designed self-organizing multicellular systems with increased robustness and physiological relevance.
Editor:
United States: Elsevier Inc
Idioma:
Inglês
Links
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