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Cancer metabolism within tumor microenvironments

Aki, Sho ; Nakahara, Ryuichi ; Maeda, Keisuke ; Osawa, Tsuyoshi

Biochimica et biophysica acta. General subjects, 2023-05, Vol.1867 (5), p.130330-130330, Article 130330 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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  • Título:
    Cancer metabolism within tumor microenvironments
  • Autor: Aki, Sho ; Nakahara, Ryuichi ; Maeda, Keisuke ; Osawa, Tsuyoshi
  • Assuntos: Acidic pH ; Cancer metabolism ; Cell Hypoxia ; Cell-cell interactions ; Humans ; Hypoxia ; Neoplasms - metabolism ; Nutrient starvation ; Organelle ; Tumor Microenvironment
  • É parte de: Biochimica et biophysica acta. General subjects, 2023-05, Vol.1867 (5), p.130330-130330, Article 130330
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Background: Tumor microenvironments could determine cancer heterogeneity and malignancy. Hypoxia, nutrition starvation, and acidic pH could contribute to cancer malignancy associated with genetic, epigenetic, and metabolic alterations, promoting invasion and metastasis. Cancer cells adapting to extreme tumor microenvironments could enable evasion of cell death and immune responses. It could stimulate drug resistance and recurrence, resulting in poor patient prognosis. Therefore, investigating druggable targets of the malignant cancer cells within tumor microenvironments is necessary, but such treatments are limited. Cell-cell metabolic interaction may also contribute to cancer malignancy within the tumor microenvironments. Organelle-organelle interactions have recently gained attention as new cancer therapy targets as they play essential roles in the metabolic adaptation to the tumor microenvironment. In this review, we overview (1) metabolic alterations within tumor microenvironments, (2) cell-to-cell, and (3) organelle-to-organelle metabolic interactions, and we add novel insights into cancer therapy. •Tumor microenvironments could determine cancer heterogeneity and malignancy.•Cancer cells adapt to extreme tumor microenvironments by altering cancer metabolism.•Non-cancerous cells in TME support tumor growth through metabolic crosstalk.•Organelle-organelle communication could be involved in essential features of cancer.
  • Editor: Netherlands: Elsevier B.V
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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