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Maternal Glycemic Spectrum and Adverse Pregnancy and Perinatal Outcomes in a Multiracial US Cohort

Kwapong, Yaa Adoma ; Boakye, Ellen ; Wang, Guoying ; Hong, Xiumei ; Lewey, Jennifer ; Mamas, Mamas Andreas ; Wu, Pensee ; Blaha, Michael Joseph ; Nasir, Khurram ; Hays, Allison Gamboa ; Blumenthal, Roger Scott ; Wang, Xiaobin ; Sharma, Garima

Journal of cardiovascular development and disease, 2022-06, Vol.9 (6), p.179 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Maternal Glycemic Spectrum and Adverse Pregnancy and Perinatal Outcomes in a Multiracial US Cohort
Autor: Kwapong, Yaa Adoma ; Boakye, Ellen ; Wang, Guoying ; Hong, Xiumei ; Lewey, Jennifer ; Mamas, Mamas Andreas ; Wu, Pensee ; Blaha, Michael Joseph ; Nasir, Khurram ; Hays, Allison Gamboa ; Blumenthal, Roger Scott ; Wang, Xiaobin ; Sharma, Garima
Assuntos: adverse pregnancy outcomes ; Birth weight ; Blood pressure ; Body mass index ; Cardiovascular disease ; cardiovascular risk ; Cesarean section ; Diabetes ; Electronic health records ; Ethnicity ; Gestational age ; gestational diabetes ; Glucose ; glycemia ; Gynecology ; Hispanic Americans ; Hypertension ; Laboratories ; Medical records ; Preeclampsia ; Pregnancy ; Premature birth ; Risk factors ; Sociodemographics ; Womens health
É parte de: Journal of cardiovascular development and disease, 2022-06, Vol.9 (6), p.179
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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These authors contributed equally to this work.
Descrição: Diabetes mellitus (pregestational (PDM) and gestational (GDM)) is associated with adverse pregnancy outcomes (APOs). However, studies exploring the association of APOs with maternal glycemia among women without PDM/GDM are limited. We utilized data from 4119 women (307-PDM; 582-GDM; 3230-non-PDM/GDM) in the Boston Birth Cohort (1998-2016). Women in the non-PDM/GDM group were subdivided by tertiles of 1 h, 50 g oral glucose load test at 24-32 weeks: T1: 50-95 mg/dL ( = 1166), T2: 96-116 mg/dL ( = 1151), T3: 117-201 mg/dL ( = 913). Using multivariable logistic regression, we examined the association of maternal glycemia with APOs-preterm birth (PTB) and hypertensive disorders of pregnancy (HDP)-and adverse perinatal outcomes-high birth weight (HBW), cesarean section (CS), and sub-analyses by race-ethnicity. Compared to women in T1, women in T2 and T3 had a higher prevalence of pre-existing hypertension (T1: 2.8% vs. T2: 5.2% vs. T3: 6.3%) and obesity (T1: 13.3% vs. T2: 18.1% vs. T3: 22.9%). Women in T2 and T3 had higher odds of HBW (adjusted odds ratio aOR T2: 1.47 [1.01-2.19] T3: 1.68 [1.13-2.50]) compared to women in T1. Additionally, women in T2, compared to T1, had higher odds of HDP (aOR 1.44 [1.10-1.88]). Among non-Hispanic Black (NHB) women, those in T2 and T3 had higher odds of HDP compared to T1 (aOR T2 1.67 [1.13-2.51]; T3: 1.68 [1.07-2.62]). GDM and PDM were associated with higher odds of HBW, CS, PTB, and HDP, compared to women in T1. In this predominantly NHB and Hispanic cohort, moderate maternal glycemia without PDM/GDM was associated with higher odds of HBW and HDP, even more strongly among NHB women. If confirmed, a review of current guidelines of glucose screening and risk stratification in pregnancy may be warranted.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Maternal Glycemic Spectrum and Adverse Pregnancy and Perinatal Outcomes in a Multiracial US Cohort

Kwapong, Yaa Adoma ; Boakye, Ellen ; Wang, Guoying ; Hong, Xiumei ; Lewey, Jennifer ; Mamas, Mamas Andreas ; Wu, Pensee ; Blaha, Michael Joseph ; Nasir, Khurram ; Hays, Allison Gamboa ; Blumenthal, Roger Scott ; Wang, Xiaobin ; Sharma, Garima

Switzerland: MDPI AG

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