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Divalent ligand-monovalent molecule binding

Janssen, Mathijs ; Stenmark, Harald ; Carlson, Andreas

Soft matter, 2021-06, Vol.17 (21), p.5375-5383 [Periódico revisado por pares]

England: Royal Society of Chemistry

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  • Título:
    Divalent ligand-monovalent molecule binding
  • Autor: Janssen, Mathijs ; Stenmark, Harald ; Carlson, Andreas
  • Assuntos: Antigens ; Binding ; Biophysical Phenomena ; Cations, Divalent ; Chemistry ; Depletion ; Dilution ; Ligands ; Lipids
  • É parte de: Soft matter, 2021-06, Vol.17 (21), p.5375-5383
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Simultaneous binding of a divalent ligand to two identical monovalent molecules is a widespread phenomenon in biology and chemistry. Here, we describe how two such monovalent molecules B bind to a divalent ligand AA to form the intermediate and final complexes AA·B and AA·B 2 . Cases wherein the total concentration [AA] T is either much larger or much smaller than the total concentration [B] T have been studied earlier, but a systematic description of comparable concentrations [AA] T and [B] T is missing. Here, we present numerical and analytical results for the concentrations [AA·B] and [AA·B 2 ] for the entire range 0 < [B] T /[AA] T < ∞. Specifically, we theoretically study three types of experimental procedures: dilution of AA and B at fixed [B] T /[AA] T , addition of AA at fixed [B] T , and addition of B at fixed [AA] T . When [AA] T and [B] T are comparable, the concentrations of free ligands and molecules both decrease upon binding. Such depletion is expected to be important in cellular contexts, e.g. , in antigen detection and in coincidence detection of proteins or lipids. Simultaneous binding of a divalent ligand to two identical monovalent molecules is a widespread phenomenon in biology and chemistry. This article presents results for the concentrations of bound complexes for arbitrary ratios of ligand-to-molecule concentrations.
  • Editor: England: Royal Society of Chemistry
  • Idioma: Inglês;Norueguês
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