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Novel Harmonization Method for Multi-Centric Radiomic Studies in Non-Small Cell Lung Cancer

Bertolini, Marco ; Trojani, Valeria ; Botti, Andrea ; Cucurachi, Noemi ; Galaverni, Marco ; Cozzi, Salvatore ; Borghetti, Paolo ; La Mattina, Salvatore ; Pastorello, Edoardo ; Avanzo, Michele ; Revelant, Alberto ; Sepulcri, Matteo ; Paronetto, Chiara ; Ursino, Stefano ; Malfatti, Giulia ; Giaj-Levra, Niccolò ; Falcinelli, Lorenzo ; Iotti, Cinzia ; Iori, Mauro ; Ciammella, Patrizia

Current oncology (Toronto), 2022-07, Vol.29 (8), p.5179-5194 [Periódico revisado por pares]

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Título:
Novel Harmonization Method for Multi-Centric Radiomic Studies in Non-Small Cell Lung Cancer
Autor: Bertolini, Marco ; Trojani, Valeria ; Botti, Andrea ; Cucurachi, Noemi ; Galaverni, Marco ; Cozzi, Salvatore ; Borghetti, Paolo ; La Mattina, Salvatore ; Pastorello, Edoardo ; Avanzo, Michele ; Revelant, Alberto ; Sepulcri, Matteo ; Paronetto, Chiara ; Ursino, Stefano ; Malfatti, Giulia ; Giaj-Levra, Niccolò ; Falcinelli, Lorenzo ; Iotti, Cinzia ; Iori, Mauro ; Ciammella, Patrizia
Assuntos: Cancer ; computed tomography (ct) ; CT imaging ; Development and progression ; imaging biomarkers and radiomics ; Lung cancer, Non-small cell ; Lung cancer, Small cell ; machine learning ; Methods ; multi-modality ct-positron emission tomography (pet) ; non-small-cell lung cancer ; Oncology, Experimental ; PET imaging ; quantitative imaging/analysis ; Radiotherapy
É parte de: Current oncology (Toronto), 2022-07, Vol.29 (8), p.5179-5194
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The purpose of this multi-centric work was to investigate the relationship between radiomic features extracted from pre-treatment computed tomography (CT), positron emission tomography (PET) imaging, and clinical outcomes for stereotactic body radiation therapy (SBRT) in early-stage non-small cell lung cancer (NSCLC). One-hundred and seventeen patients who received SBRT for early-stage NSCLC were retrospectively identified from seven Italian centers. The tumor was identified on pre-treatment free-breathing CT and PET images, from which we extracted 3004 quantitative radiomic features. The primary outcome was 24-month progression-free-survival (PFS) based on cancer recurrence (local/non-local) following SBRT. A harmonization technique was proposed for CT features considering lesion and contralateral healthy lung tissues using the LASSO algorithm as a feature selector. Models with harmonized CT features (B models) demonstrated better performances compared to the ones using only original CT features (C models). A linear support vector machine (SVM) with harmonized CT and PET features (A1 model) showed an area under the curve (AUC) of 0.77 (0.63–0.85) for predicting the primary outcome in an external validation cohort. The addition of clinical features did not enhance the model performance. This study provided the basis for validating our novel CT data harmonization strategy, involving delta radiomics. The harmonized radiomic models demonstrated the capability to properly predict patient prognosis.
Editor: MDPI AG
Idioma: Inglês

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Novel Harmonization Method for Multi-Centric Radiomic Studies in Non-Small Cell Lung Cancer

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