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Comparative genomics of emerging human ehrlichiosis agents

Dunning Hotopp, Julie C ; Lin, Mingqun ; Madupu, Ramana ; Crabtree, Jonathan ; Angiuoli, Samuel V ; Eisen, Jonathan A ; Eisen, Jonathan ; Seshadri, Rekha ; Ren, Qinghu ; Wu, Martin ; Utterback, Teresa R ; Smith, Shannon ; Lewis, Matthew ; Khouri, Hoda ; Zhang, Chunbin ; Niu, Hua ; Lin, Quan ; Ohashi, Norio ; Zhi, Ning ; Nelson, William ; Brinkac, Lauren M ; Dodson, Robert J ; Rosovitz, M J ; Sundaram, Jaideep ; Daugherty, Sean C ; Davidsen, Tanja ; Durkin, Anthony S ; Gwinn, Michelle ; Haft, Daniel H ; Selengut, Jeremy D ; Sullivan, Steven A ; Zafar, Nikhat ; Zhou, Liwei ; Benahmed, Faiza ; Forberger, Heather ; Halpin, Rebecca ; Mulligan, Stephanie ; Robinson, Jeffrey ; White, Owen ; Rikihisa, Yasuko ; Tettelin, Hervé Richardson, Paul M.

PLoS genetics, 2006-02, Vol.2 (2), p.e21-e21 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Comparative genomics of emerging human ehrlichiosis agents
Autor: Dunning Hotopp, Julie C ; Lin, Mingqun ; Madupu, Ramana ; Crabtree, Jonathan ; Angiuoli, Samuel V ; Eisen, Jonathan A ; Eisen, Jonathan ; Seshadri, Rekha ; Ren, Qinghu ; Wu, Martin ; Utterback, Teresa R ; Smith, Shannon ; Lewis, Matthew ; Khouri, Hoda ; Zhang, Chunbin ; Niu, Hua ; Lin, Quan ; Ohashi, Norio ; Zhi, Ning ; Nelson, William ; Brinkac, Lauren M ; Dodson, Robert J ; Rosovitz, M J ; Sundaram, Jaideep ; Daugherty, Sean C ; Davidsen, Tanja ; Durkin, Anthony S ; Gwinn, Michelle ; Haft, Daniel H ; Selengut, Jeremy D ; Sullivan, Steven A ; Zafar, Nikhat ; Zhou, Liwei ; Benahmed, Faiza ; Forberger, Heather ; Halpin, Rebecca ; Mulligan, Stephanie ; Robinson, Jeffrey ; White, Owen ; Rikihisa, Yasuko ; Tettelin, Hervé
Richardson, Paul M.
Assuntos: Animals ; Bacteria ; Biotin - metabolism ; Colleges & universities ; DNA Repair ; Ehrlichia - genetics ; Ehrlichiosis - genetics ; Ehrlichiosis - microbiology ; Eubacteria ; Evolution ; Fever ; Genetics/Comparative Genomics ; Genetics/Functional Genomics ; Genetics/Genomics ; Genome ; Genomes ; Genomics ; Genomics - methods ; Humans ; Infectious Diseases ; Microbiology ; Models, Biological ; Mortality ; Organisms ; Pathogenesis ; Phylogeny ; Proteins ; Rickettsia - genetics ; Ticks
É parte de: PLoS genetics, 2006-02, Vol.2 (2), p.e21-e21
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
d Current address: Eastern Virginia Medical School, Norfolk, Virginia, United States of America
a Current address: Developmental and Regenerative Neurobiology Program, Department of Neurology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia, United States of America
c Current address: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
b Current address: Laboratory of Environmental Microbiology, Institute for Environmental Sciences, Suruga, Shizuoka, Japan
Descrição: Anaplasma (formerly Ehrlichia) phagocytophilum, Ehrlichia chaffeensis, and Neorickettsia (formerly Ehrlichia) sennetsu are intracellular vector-borne pathogens that cause human ehrlichiosis, an emerging infectious disease. We present the complete genome sequences of these organisms along with comparisons to other organisms in the Rickettsiales order. Ehrlichia spp. and Anaplasma spp. display a unique large expansion of immunodominant outer membrane proteins facilitating antigenic variation. All Rickettsiales have a diminished ability to synthesize amino acids compared to their closest free-living relatives. Unlike members of the Rickettsiaceae family, these pathogenic Anaplasmataceae are capable of making all major vitamins, cofactors, and nucleotides, which could confer a beneficial role in the invertebrate vector or the vertebrate host. Further analysis identified proteins potentially involved in vacuole confinement of the Anaplasmataceae, a life cycle involving a hematophagous vector, vertebrate pathogenesis, human pathogenesis, and lack of transovarial transmission. These discoveries provide significant insights into the biology of these obligate intracellular pathogens.
Editor: United States: Public Library of Science
Idioma: Inglês

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Comparative genomics of emerging human ehrlichiosis agents

United States: Public Library of Science

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