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Beyond Gene Discovery in Inflammatory Bowel Disease: The Emerging Role of Epigenetics

Ventham, Nicholas T ; Kennedy, Nicholas A ; Nimmo, Elaine R ; Satsangi, Jack

Gastroenterology (New York, N.Y. 1943), 2013-08, Vol.145 (2), p.293-308 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Beyond Gene Discovery in Inflammatory Bowel Disease: The Emerging Role of Epigenetics
Autor: Ventham, Nicholas T ; Kennedy, Nicholas A ; Nimmo, Elaine R ; Satsangi, Jack
Assuntos: Colitis, Ulcerative - genetics ; Crohn Disease - genetics ; Crohn’s Disease ; DNA Methylation ; Epigenesis, Genetic ; Epigenetics ; Epigenomics ; Gastroenterology and Hepatology ; Genetic Predisposition to Disease ; Humans ; Reviews and s ; Ulcerative Colitis
É parte de: Gastroenterology (New York, N.Y. 1943), 2013-08, Vol.145 (2), p.293-308
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: In the past decade, there have been fundamental advances in our understanding of genetic factors that contribute to the inflammatory bowel diseases (IBDs) Crohn’s disease and ulcerative colitis. The latest international collaborative studies have brought the number of IBD susceptibility gene loci to 163. However, genetic factors account for only a portion of overall disease variance, indicating a need to better explore gene-environment interactions in the development of IBD. Epigenetic factors can mediate interactions between the environment and the genome; their study could provide new insight into the pathogenesis of IBD. We review recent progress in identification of genetic factors associated with IBD and discuss epigenetic mechanisms that could affect development and progression of IBD.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Beyond Gene Discovery in Inflammatory Bowel Disease: The Emerging Role of Epigenetics

Ventham, Nicholas T ; Kennedy, Nicholas A ; Nimmo, Elaine R ; Satsangi, Jack

United States: Elsevier Inc

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