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Structure-activity Relationships of Cephalosporin Derivatives against Methicillin-resistant Staphylococcus aureus and Enterococcus faecalis

HANAKI, HIDEAKI ; AKAGI, HIROSHI ; NOMURA, SHUICHI ; UNEMI, NORIO ; HIRAMATSU, KEIICHI

The Journal of Antibiotics, 1996/04/25, Vol.49(4), pp.402-404 [Periódico revisado por pares]

Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

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Título:
Structure-activity Relationships of Cephalosporin Derivatives against Methicillin-resistant Staphylococcus aureus and Enterococcus faecalis
Autor: HANAKI, HIDEAKI ; AKAGI, HIROSHI ; NOMURA, SHUICHI ; UNEMI, NORIO ; HIRAMATSU, KEIICHI
Assuntos: Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Cephalosporins - chemistry ; Cephalosporins - pharmacology ; Enterococcus faecalis ; Enterococcus faecalis - drug effects ; Medical sciences ; Methicillin Resistance ; Microbial Sensitivity Tests ; Pharmacology. Drug treatments ; Staphylococcus aureus - drug effects ; Structure-Activity Relationship
É parte de: The Journal of Antibiotics, 1996/04/25, Vol.49(4), pp.402-404
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ObjectType-Article-1
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Descrição: We investigated the activity of various cephalosporin derivatives toward MRSA and E. faecalis. We already reported that hydroxyimino-aminothiazol at the C-7 position of 2-thioisocephem having a vinyl-thio linkage at C-3 showed strong activity against MRSA and E. faecalis and that the same on 1-thiocephem showed the strongest activity against MRSA and E. faecalis. In this present communication, we describe that the anti-MRSA and anti-E. faecalis activities of 1-thiocephem having hydroxy-amino-aminothiazol at the C-7 position and the vinyl-thio linkage at C-3 were changed by varying the C-3 side chain.
Editor: Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
Idioma: Inglês

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Structure-activity Relationships of Cephalosporin Derivatives against Methicillin-resistant Staphylococcus aureus and Enterococcus faecalis

HANAKI, HIDEAKI ; AKAGI, HIROSHI ; NOMURA, SHUICHI ; UNEMI, NORIO ; HIRAMATSU, KEIICHI

Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

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