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The Interplay between Endocrine-Disrupting Chemicals and the Epigenome towards Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive Review

Mentsiou Nikolaou, Evangelia ; Kalafati, Ioanna Panagiota ; Dedoussis, George V

Nutrients, 2024-04, Vol.16 (8), p.1124 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
The Interplay between Endocrine-Disrupting Chemicals and the Epigenome towards Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive Review
Autor: Mentsiou Nikolaou, Evangelia ; Kalafati, Ioanna Panagiota ; Dedoussis, George V
Assuntos: Animals ; Development and progression ; diet ; Disease susceptibility ; DNA methylation ; Endocrine disruptors ; Endocrine Disruptors - adverse effects ; endocrine-disrupting chemicals (EDCs) ; Epigenesis, Genetic ; epigenetic changes ; Epigenetic inheritance ; Epigenetics ; Epigenome ; Fatty Liver - chemically induced ; Fatty Liver - genetics ; Genetic aspects ; Health aspects ; histone alterations ; Humans ; Liver diseases ; Metabolic Diseases - chemically induced ; Metabolic Diseases - genetics ; metabolic dysfunction-associated steatotic liver disease (MASLD) ; MicroRNAs ; Non-alcoholic Fatty Liver Disease - genetics ; Pesticides ; Receptors, Cytoplasmic and Nuclear - genetics ; Receptors, Cytoplasmic and Nuclear - metabolism ; Review ; Type 2 diabetes
É parte de: Nutrients, 2024-04, Vol.16 (8), p.1124
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: Metabolic dysfunction-associated steatotic liver disease (MASLD), described as the most prominent cause of chronic liver disease worldwide, has emerged as a significant public health issue, posing a considerable challenge for most countries. Endocrine-disrupting chemicals (EDCs), commonly found in daily use items and foods, are able to interfere with nuclear receptors (NRs) and disturb hormonal signaling and mitochondrial function, leading, among other metabolic disorders, to MASLD. EDCs have also been proposed to cause transgenerationally inherited alterations leading to increased disease susceptibility. In this review, we are focusing on the most prominent linking pathways between EDCs and MASLD, their role in the induction of epigenetic transgenerational inheritance of the disease as well as up-to-date practices aimed at reducing their impact.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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The Interplay between Endocrine-Disrupting Chemicals and the Epigenome towards Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive Review

Mentsiou Nikolaou, Evangelia ; Kalafati, Ioanna Panagiota ; Dedoussis, George V

Switzerland: MDPI AG

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