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Optimized enzymatic synthesis of hesperidin fatty acid esters in a two-phase system containing ionic liquid

de Araújo, Maria Elisa Melo Branco ; Contesini, Fabiano Jares ; Franco, Yollanda Edwirges Moreira ; Sawaya, Alexandra C H Frankland ; Alberto, Thiago Grando ; Dalfré, Natália ; Carvalho, Patrícia de Oliveira

Molecules (Basel, Switzerland), 2011-08, Vol.16 (8), p.7171-7182 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Optimized enzymatic synthesis of hesperidin fatty acid esters in a two-phase system containing ionic liquid
Autor: de Araújo, Maria Elisa Melo Branco ; Contesini, Fabiano Jares ; Franco, Yollanda Edwirges Moreira ; Sawaya, Alexandra C H Frankland ; Alberto, Thiago Grando ; Dalfré, Natália ; Carvalho, Patrícia de Oliveira
Assuntos: acylation ; Analysis of Variance ; Antioxidants ; Biocatalysis ; Candida - enzymology ; Candida antarctica ; Citrus fruits ; Decanoic Acids - chemical synthesis ; Enzymes ; Enzymes, Immobilized - chemistry ; Esters ; Fatty acids ; Flavonoids ; Food ; Free radicals ; Fungal Proteins ; hesperidin ; Hesperidin - analogs & derivatives ; Hesperidin - chemical synthesis ; Imidazoles - chemistry ; Ionic Liquids - chemistry ; Kinetics ; lipase ; Lipase - chemistry
É parte de: Molecules (Basel, Switzerland), 2011-08, Vol.16 (8), p.7171-7182
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Response surface methodology (RSM) based on a five-level, three-variable central composite design (CCD) was employed for modeling and optimizing the conversion yield of the enzymatic acylation of hesperidin with decanoic acid using immobilized Candida antarctica lipase B (CALB) in a two-phase system containing [bmim]BF(4). The three variables studied (molar ratio of hesperidin to decanoic acid, [bmim]BF(4)/acetone ratio and lipase concentration) significantly affected the conversion yield of acylated hesperidin derivative. Verification experiments confirmed the validity of the predicted model. The lipase showed higher conversion degree in a two-phase system using [bmim]BF(4) and acetone compared to that in pure acetone. Under the optimal reaction conditions carried out in a single-step biocatalytic process when the water content was kept lower than 200 ppm, the maximum acylation yield was 53.6%.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Optimized enzymatic synthesis of hesperidin fatty acid esters in a two-phase system containing ionic liquid

de Araújo, Maria Elisa Melo Branco ; Contesini, Fabiano Jares ; Franco, Yollanda Edwirges Moreira ; Sawaya, Alexandra C H Frankland ; Alberto, Thiago Grando ; Dalfré, Natália ; Carvalho, Patrícia de Oliveira

Switzerland: MDPI AG

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