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Antimicrobial Efficacy and Synergy of Metal Ions against Enterococcus faecium, Klebsiella pneumoniae and Acinetobacter baumannii in Planktonic and Biofilm Phenotypes

Vaidya, Misha Y ; McBain, Andrew J ; Butler, Jonathan A ; Banks, Craig E ; Whitehead, Kathryn A

Scientific reports, 2017-07, Vol.7 (1), p.5911-9, Article 5911 [Periódico revisado por pares]

England: Nature Publishing Group

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Antimicrobial Efficacy and Synergy of Metal Ions against Enterococcus faecium, Klebsiella pneumoniae and Acinetobacter baumannii in Planktonic and Biofilm Phenotypes
Autor: Vaidya, Misha Y ; McBain, Andrew J ; Butler, Jonathan A ; Banks, Craig E ; Whitehead, Kathryn A
Assuntos: Acinetobacter baumannii ; Acinetobacter baumannii - drug effects ; Anti-Infective Agents - pharmacology ; Antimicrobial agents ; Bacteria ; Bactericidal activity ; Biofilms ; Biofilms - drug effects ; Biofilms - growth & development ; Copper ; Enterococcus faecium ; Enterococcus faecium - drug effects ; Heavy metals ; Ions ; Klebsiella pneumoniae ; Klebsiella pneumoniae - drug effects ; Metals ; Metals - pharmacology ; Microbial Sensitivity Tests ; Palladium ; Phenotype ; Plankton - drug effects ; Platinum ; Silver
É parte de: Scientific reports, 2017-07, Vol.7 (1), p.5911-9, Article 5911
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SourceType-Scholarly Journals-1
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Descrição: The effects of metal ion solutions (silver, copper, platinum, gold and palladium) were determined individually and in combination against Enterococcus faecium, Acinetobacter baumannii and Klebsiella pneumoniae. Platinum, gold and palladium showed the greatest antimicrobial efficacy in zone of inhibition (ZoI) assays. When tested in combinations using ZoI assays, gold/platinum, gold/palladium and platinum/palladium were indicative of synergy. Microbial inhibitory concentration demonstrated platinum and gold against Enterococcus faecium, platinum against Klebsiella pneumoniae and platinum and silver against Acinetobacter baumannii were optimal. Minimal bactericidal concentrations determined the greatest bactericidal activity was again platinum gold and palladium against all three bacteria. Fractional Inhibitory Concentration (FIC) studies demonstrated that the silver/platinum combination against Enterococcus faecium, and silver/copper combination against Acinetobacter baumannii demonstrated antimicrobial synergy. Following crystal violet biofilm assays for single metal ion solutions, antimicrobial efficacies were demonstrated for all the metals against all the bacteria Synergistic assays against biofilms demonstrated gold/palladium, gold/platinumand platinum/palladium resulted in the greatest antimicrobial efficacy. Overall, platinum, palladium and gold metal ion solutions in individual use or combination demonstrated the greatest antimicrobial efficacies against planktonic or biofilm bacteria. This work demonstrates the potential for using a range of metal ions, as biocidal formulations against both planktonic or biofilm bacteria.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Antimicrobial Efficacy and Synergy of Metal Ions against Enterococcus faecium, Klebsiella pneumoniae and Acinetobacter baumannii in Planktonic and Biofilm Phenotypes

Vaidya, Misha Y ; McBain, Andrew J ; Butler, Jonathan A ; Banks, Craig E ; Whitehead, Kathryn A

England: Nature Publishing Group

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