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Long-Term Effects of Amino-Bisphosphonates on Circulating γδ T Cells

Rossini, Maurizio ; Adami, Silvano ; Viapiana, Ombretta ; Fracassi, Elena ; Ortolani, Riccardo ; Vella, Antonio ; Zanotti, Roberta ; Tripi, Gaia ; Idolazzi, Luca ; Gatti, Davide

Calcified tissue international, 2012-12, Vol.91 (6), p.395-399 [Periódico revisado por pares]

New York: Springer-Verlag

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Título:
Long-Term Effects of Amino-Bisphosphonates on Circulating γδ T Cells
Autor: Rossini, Maurizio ; Adami, Silvano ; Viapiana, Ombretta ; Fracassi, Elena ; Ortolani, Riccardo ; Vella, Antonio ; Zanotti, Roberta ; Tripi, Gaia ; Idolazzi, Luca ; Gatti, Davide
Assuntos: Aged ; Aged, 80 and over ; Biochemistry ; Biomedical and Life Sciences ; Bone Density Conservation Agents - administration & dosage ; Bone Density Conservation Agents - therapeutic use ; Cell Biology ; Diphosphonates - administration & dosage ; Diphosphonates - pharmacology ; Diphosphonates - therapeutic use ; Endocrinology ; Female ; Humans ; Imidazoles - administration & dosage ; Imidazoles - pharmacology ; Imidazoles - therapeutic use ; Life Sciences ; Lymphocyte Subsets - drug effects ; Lymphocyte Subsets - metabolism ; Lymphocyte Subsets - pathology ; Male ; Middle Aged ; Original Research ; Orthopedics ; Osteoporosis - drug therapy ; Osteoporosis - immunology ; Osteoporosis - pathology ; Receptors, Antigen, T-Cell, gamma-delta - metabolism ; T-Lymphocytes - drug effects ; T-Lymphocytes - metabolism ; Time Factors
É parte de: Calcified tissue international, 2012-12, Vol.91 (6), p.395-399
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Descrição: The aim of this study was to explore whether desensitization to the occurrence of the acute-phase response (APR) in patients previously treated with amino-bisphosphonates (N-BPs) is due to a long-lasting reduction in the number of circulating γδ T cells. Circulating lymphocyte subpopulation counts were obtained from 63 patients with postmenopausal or senile osteoporosis at baseline and after 2 days and 12 months of the first intravenous (IV) 5 mg zoledronic acid (ZOL) infusion. At baseline both the proportion and absolute number of circulating γδ T cells were significantly higher in patients who had never used N-BPs vs. previous users, either oral or IV. A typical APR was observed in none of the patients given IV ZOL a year earlier, in 6 (22 %) of the patients previously treated with oral N-BPs, and in 13 (57 %) of the patients naive to any N-BP treatment. In patients naive to N-BPs, a significant reduction in both total lymphocytes and their subsets was observed 2 days after ZOL infusion; all these changes returned to baseline values 1 year later with the exception of γδ T cells, which remained significantly lower in terms of both proportion and absolute number. These results indicate for the first time that both IV and oral N-BP treatments are associated with a long-lasting decrease in circulating γδ T cells, and this may explain the lower incidence of APR in patients previously exposed to N-BPs. Other clinical implications of this sustained effect of N-BPs on immune-regulatory cells might be important.
Editor: New York: Springer-Verlag
Idioma: Inglês

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Long-Term Effects of Amino-Bisphosphonates on Circulating γδ T Cells

Rossini, Maurizio ; Adami, Silvano ; Viapiana, Ombretta ; Fracassi, Elena ; Ortolani, Riccardo ; Vella, Antonio ; Zanotti, Roberta ; Tripi, Gaia ; Idolazzi, Luca ; Gatti, Davide

New York: Springer-Verlag

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