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Molecular Biotypes for Periodontal Diseases?

Loos, B.G. ; Papantonopoulos, G.

Journal of dental research, 2013-12, Vol.92 (12), p.1056-1057 [Periódico revisado por pares]

Los Angeles, CA: SAGE Publications

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Título:
Molecular Biotypes for Periodontal Diseases?
Autor: Loos, B.G. ; Papantonopoulos, G.
Assuntos: Aggressive Periodontitis - etiology ; Aggressive Periodontitis - genetics ; Aggressive Periodontitis - microbiology ; Bacterial Physiological Phenomena ; Biofilms ; Biopsy ; Biotypes ; Chronic Periodontitis - etiology ; Chronic Periodontitis - genetics ; Chronic Periodontitis - microbiology ; Complex systems ; Dentistry ; Disease ; Evolution ; Feedback ; Gene expression ; Genetic diversity ; Genetic Variation - genetics ; Gum disease ; Homeostasis ; Humans ; Immune response ; Life Style ; Lifestyles ; Microbiota ; Nonlinear Dynamics ; Optimization techniques ; Periodontal diseases ; Periodontitis ; Periodontitis - etiology ; Periodontitis - genetics ; Periodontitis - microbiology ; Phenotype ; Phenotypes ; Risk Factors ; Transcription factors ; Transcriptome - genetics
É parte de: Journal of dental research, 2013-12, Vol.92 (12), p.1056-1057
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Commentary-1
Descrição: Since the introduction of 2 forms of periodontitis, chronic periodontitis (CP) and aggressive periodontitis (AgP) (Armitage, 1999), based on major differences in clinical phenotypes, questions still remain regarding the exact biological features that correspond to the separation of destructive periodontal disease into these 2 entities. There are several attributes of complexity that are well-recognized: (1) The emergence of the behavior of a complex system cannot be explained by consideration of its contributing parts separately (the whole does not equal the sum of the parts); (2) there is always a mixture of regularity and chance in the description of a complex system; (3) a complex system cannot be static and therefore undergoes continuous state and scale transformations; (4) for the transformations to begin, a tuning parameter must surpass a critical threshold, and the system enters a state out of equilibrium; (5) there is always an element of surprise in the behavior of a complex system, due to sensitivity to initial conditions (the basic characteristic of chaos); (6) the basic feature of a complex system’s evolution in time and space is multiplicity, which is based on the non-linear relationships of its parameters (non-linearity is ubiquitous in nature); and (7) the complex system’s evolution depends on external and/or internal feedback. [...]because of the complexity of periodontitis, we must recognize that there does not seem to be a single “test” to discriminate AgP from CP – not microbiology on its own, nor histopathology, nor genetic variations or unfavorable lifestyle factors, nor solely transcriptional signatures in periodontitis lesions. (2013), a recent mathematical approach has identified, in a database of periodontitis patients, 2 zones of disease activity corresponding to CP and AgP, based on the hypothesis that the immune response level determines the system’s evolution (Papantonopoulos et al., 2013).
Editor: Los Angeles, CA: SAGE Publications
Idioma: Inglês

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Molecular Biotypes for Periodontal Diseases?

Loos, B.G. ; Papantonopoulos, G.

Los Angeles, CA: SAGE Publications

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